No-Reflow Phenomenon and Endothelial Glycocalyx of Microcirculation
The progress in reperfusion therapy dictated the necessity for developing new tools and procedures for adjacent/additional therapy of acute cardiovascular disorders. The adjacent therapy is targeted on the damage of the microcirculation, leading to the unfavorable prognosis for the patients. The no-...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/859231 |
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| author | Alexander V. Maksimenko Askar D. Turashev |
| author_facet | Alexander V. Maksimenko Askar D. Turashev |
| author_sort | Alexander V. Maksimenko |
| collection | DOAJ |
| description | The progress in reperfusion therapy dictated the necessity for developing new tools and procedures for adjacent/additional therapy of acute cardiovascular disorders. The adjacent therapy is targeted on the damage of the microcirculation, leading to the unfavorable prognosis for the patients. The no-reflow phenomenon holds special place in the multifactorial etiology of the microcirculation disorders, offering a new challenge in treating the patients associated with ST-segment elevation on ECG at myocardial infarction. One of the numerous causes of no-reflow, the influence of the endothelial glycocalyx of the microcirculation, is analyzed. The results obtained in the studies of the endothelial glycocalyx ultrastructure are generalized, the effect that the fragments of the glycocalyx glycosaminoglycans have on the function of the vascular wall is demonstrated. The trends in searching for correlations between the thickness of the capillary glycocalyx and the cardiovascular disease risk are noted. |
| format | Article |
| id | doaj-art-c54b06d02aec42ee9d61cc022c84afa4 |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-c54b06d02aec42ee9d61cc022c84afa42025-02-03T05:47:52ZengWileyBiochemistry Research International2090-22472090-22552012-01-01201210.1155/2012/859231859231No-Reflow Phenomenon and Endothelial Glycocalyx of MicrocirculationAlexander V. Maksimenko0Askar D. Turashev1Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, 3rd Cherepkovskaya Street 15A, Moscow 121552, RussiaInstitute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, 3rd Cherepkovskaya Street 15A, Moscow 121552, RussiaThe progress in reperfusion therapy dictated the necessity for developing new tools and procedures for adjacent/additional therapy of acute cardiovascular disorders. The adjacent therapy is targeted on the damage of the microcirculation, leading to the unfavorable prognosis for the patients. The no-reflow phenomenon holds special place in the multifactorial etiology of the microcirculation disorders, offering a new challenge in treating the patients associated with ST-segment elevation on ECG at myocardial infarction. One of the numerous causes of no-reflow, the influence of the endothelial glycocalyx of the microcirculation, is analyzed. The results obtained in the studies of the endothelial glycocalyx ultrastructure are generalized, the effect that the fragments of the glycocalyx glycosaminoglycans have on the function of the vascular wall is demonstrated. The trends in searching for correlations between the thickness of the capillary glycocalyx and the cardiovascular disease risk are noted.http://dx.doi.org/10.1155/2012/859231 |
| spellingShingle | Alexander V. Maksimenko Askar D. Turashev No-Reflow Phenomenon and Endothelial Glycocalyx of Microcirculation Biochemistry Research International |
| title | No-Reflow Phenomenon and Endothelial Glycocalyx of Microcirculation |
| title_full | No-Reflow Phenomenon and Endothelial Glycocalyx of Microcirculation |
| title_fullStr | No-Reflow Phenomenon and Endothelial Glycocalyx of Microcirculation |
| title_full_unstemmed | No-Reflow Phenomenon and Endothelial Glycocalyx of Microcirculation |
| title_short | No-Reflow Phenomenon and Endothelial Glycocalyx of Microcirculation |
| title_sort | no reflow phenomenon and endothelial glycocalyx of microcirculation |
| url | http://dx.doi.org/10.1155/2012/859231 |
| work_keys_str_mv | AT alexandervmaksimenko noreflowphenomenonandendothelialglycocalyxofmicrocirculation AT askardturashev noreflowphenomenonandendothelialglycocalyxofmicrocirculation |