High CIB1 expression in colorectal cancer liver metastases correlates with worse survival and the replacement histopathological growth pattern

High CIB1 expression in colorectal cancer liver metastases correlates with worse survival and the replacement histopathological growth pattern

To date, nearly one-quarter of colorectal cancer (CRC) patients develop liver metastases (CRCLM), and its aggressiveness can be correlated to defined histopathological growth patterns (HGP). From the three main HGPs within CRCLM, the replacement HGP emerges as particularly aggressive, characterized...

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Main Authors: Shuang Fan, Johannes Robert Fleischer, Lolita Dokshokova, Lena Sophie Böhme, Gwendolyn Haas, Alexandra Maria Schmitt, Fabio Bennet Gätje, Linde-Allegra Emmalie Rosen, Hanibal Bohnenberger, Michael Ghadimi, Baolong Cui, Xingbo Xu, Joanna Maria Kalucka, Florian Bösch, Tiago De Oliveira, Lena-Christin Conradi
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
CIB1
colorectal cancer
histopathological growth patterns of liver metastasis
single-cell RNA sequencing
spatial transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924000705
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