The Potential of MicroRNAs as Novel Biomarkers for Transplant Rejection
The control of gene expression by microRNAs (miRNAs, miR) influences many cellular functions, including cellular differentiation, cell proliferation, cell development, and functional regulation of the immune system. Recently, miRNAs have been detected in serum, plasma, and urine and circulating miR...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/4072364 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548917683683328 |
|---|---|
| author | Matthias Hamdorf Satoru Kawakita Matthew Everly |
| author_facet | Matthias Hamdorf Satoru Kawakita Matthew Everly |
| author_sort | Matthias Hamdorf |
| collection | DOAJ |
| description | The control of gene expression by microRNAs (miRNAs, miR) influences many cellular functions, including cellular differentiation, cell proliferation, cell development, and functional regulation of the immune system. Recently, miRNAs have been detected in serum, plasma, and urine and circulating miR profiles have been associated with a variety of diseases. Rejection is one of the major causes of allograft failure and preventing and treating acute rejection are the central task for clinicians working with transplant patients. Invasive biopsies used in monitoring rejection are burdensome and risky to transplant patients. Novel and easily accessible biomarkers of acute rejection could make it possible to detect rejection earlier and make more fine-tuned calibration of immunosuppressive or new target treatment possible. In this review, we discuss whether circulating miRNA can serve as an early noninvasive diagnostic biomarker and an expression fingerprint of allograft rejection and transplant failure. Understanding the regulatory interplay of relevant miRNAs and the rejecting allograft will result in a better understanding of the molecular pathophysiology of alloimmune injury. |
| format | Article |
| id | doaj-art-c51c9ff7ed4a4975a8bfdcfb14ce37eb |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-c51c9ff7ed4a4975a8bfdcfb14ce37eb2025-02-03T06:12:40ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/40723644072364The Potential of MicroRNAs as Novel Biomarkers for Transplant RejectionMatthias Hamdorf0Satoru Kawakita1Matthew Everly2Terasaki Foundation Laboratory, 11570 W. Olympic Blvd., Los Angeles, CA 90064, USATerasaki Foundation Laboratory, 11570 W. Olympic Blvd., Los Angeles, CA 90064, USATerasaki Foundation Laboratory, 11570 W. Olympic Blvd., Los Angeles, CA 90064, USAThe control of gene expression by microRNAs (miRNAs, miR) influences many cellular functions, including cellular differentiation, cell proliferation, cell development, and functional regulation of the immune system. Recently, miRNAs have been detected in serum, plasma, and urine and circulating miR profiles have been associated with a variety of diseases. Rejection is one of the major causes of allograft failure and preventing and treating acute rejection are the central task for clinicians working with transplant patients. Invasive biopsies used in monitoring rejection are burdensome and risky to transplant patients. Novel and easily accessible biomarkers of acute rejection could make it possible to detect rejection earlier and make more fine-tuned calibration of immunosuppressive or new target treatment possible. In this review, we discuss whether circulating miRNA can serve as an early noninvasive diagnostic biomarker and an expression fingerprint of allograft rejection and transplant failure. Understanding the regulatory interplay of relevant miRNAs and the rejecting allograft will result in a better understanding of the molecular pathophysiology of alloimmune injury.http://dx.doi.org/10.1155/2017/4072364 |
| spellingShingle | Matthias Hamdorf Satoru Kawakita Matthew Everly The Potential of MicroRNAs as Novel Biomarkers for Transplant Rejection Journal of Immunology Research |
| title | The Potential of MicroRNAs as Novel Biomarkers for Transplant Rejection |
| title_full | The Potential of MicroRNAs as Novel Biomarkers for Transplant Rejection |
| title_fullStr | The Potential of MicroRNAs as Novel Biomarkers for Transplant Rejection |
| title_full_unstemmed | The Potential of MicroRNAs as Novel Biomarkers for Transplant Rejection |
| title_short | The Potential of MicroRNAs as Novel Biomarkers for Transplant Rejection |
| title_sort | potential of micrornas as novel biomarkers for transplant rejection |
| url | http://dx.doi.org/10.1155/2017/4072364 |
| work_keys_str_mv | AT matthiashamdorf thepotentialofmicrornasasnovelbiomarkersfortransplantrejection AT satorukawakita thepotentialofmicrornasasnovelbiomarkersfortransplantrejection AT mattheweverly thepotentialofmicrornasasnovelbiomarkersfortransplantrejection AT matthiashamdorf potentialofmicrornasasnovelbiomarkersfortransplantrejection AT satorukawakita potentialofmicrornasasnovelbiomarkersfortransplantrejection AT mattheweverly potentialofmicrornasasnovelbiomarkersfortransplantrejection |