Short‐Term Statin Therapy Induces Hepatic Insulin Resistance Through HNF4α/PAQR9/PPM1α Axis Regulated AKT Phosphorylation

Short‐Term Statin Therapy Induces Hepatic Insulin Resistance Through HNF4α/PAQR9/PPM1α Axis Regulated AKT Phosphorylation

Abstract Statins, the first‐line medication for dyslipidemia, are linked to an increased risk of type 2 diabetes. But exactly how statins cause diabetes is yet unknown. In this study, a developed short‐term statin therapy on hyperlipidemia mice show that hepatic insulin resistance is a cause of stat...

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Bibliographic Details
Main Authors: Yijun Lin, Shuying Wang, Zixuan Li, Yuling Zhou, Ruiying Wang, Yan Wang, Yan Chen
Format: Article
Language:English
Published: Wiley 2024-09-01
Series:Advanced Science
Subjects:
AKT phosphorylation
hepatic insulin resistance
progesterone and adiponectin receptor 9 (PAQR9)
statins
type 2 diabetes
Online Access:https://doi.org/10.1002/advs.202403451
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https://doi.org/10.1002/advs.202403451

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