Increased STAT3 Phosphorylation in CD4<sup>+</sup> T-Cells of Treated Patients with Chronic Lymphocytic Leukemia and Changes in Circulating Regulatory T-Cell Subsets Relative to Tumor Mass Distribution Value and Disease Duration

Increased STAT3 Phosphorylation in CD4<sup>+</sup> T-Cells of Treated Patients with Chronic Lymphocytic Leukemia and Changes in Circulating Regulatory T-Cell Subsets Relative to Tumor Mass Distribution Value and Disease Duration

<b>Introduction</b>: In mouse models of chronic lymphocytic leukemia (CLL), an effective anti-leukemia immune response was obtained by depleting a specific regulatory T-cell (Treg) subset. While STAT5 signaling could alter the homeostasis of naïve (nTreg) and activated (aTreg) subsets, w...

Full description

Saved in:
Bibliographic Details
Main Authors: Mojca Dreisinger, Zlatko Roškar, Aleš Goropevšek, Andreja Zakelšek, Sara Čurič, Nada Živko, Sebastjan Bevc, Evgenija Homšak
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomedicines
Subjects:
chronic lymphocytic leukemia (CLL)
signal transduction
cytokines
T-cells
Online Access:https://www.mdpi.com/2227-9059/13/5/1204
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/2227-9059/13/5/1204

Similar Items