Super High Contrast USPIO-Enhanced Cerebrovascular Angiography Using Ultrashort Time-to-Echo MRI
Background. Ferumoxytol (Ferahame, AMAG Pharmaceuticals, Waltham, MA) is increasingly used off-label as an MR contrast agent due to its relaxivity and safety profiles. However, its potent T2∗ relaxivity limits achievable T1-weighted positive contrast and leads to artifacts in standard MRI protocols....
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | International Journal of Biomedical Imaging |
| Online Access: | http://dx.doi.org/10.1155/2024/9763364 |
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| author | Liam Timms Tianyi Zhou Ju Qiao Codi Gharagouzloo Vishala Mishra Rita Maria Lahoud John W. Chen Mukesh Harisinghani Srinivas Sridhar |
| author_facet | Liam Timms Tianyi Zhou Ju Qiao Codi Gharagouzloo Vishala Mishra Rita Maria Lahoud John W. Chen Mukesh Harisinghani Srinivas Sridhar |
| author_sort | Liam Timms |
| collection | DOAJ |
| description | Background. Ferumoxytol (Ferahame, AMAG Pharmaceuticals, Waltham, MA) is increasingly used off-label as an MR contrast agent due to its relaxivity and safety profiles. However, its potent T2∗ relaxivity limits achievable T1-weighted positive contrast and leads to artifacts in standard MRI protocols. Optimization of protocols for ferumoxytol deployment is necessary to realize its potential. Methods. We present first-in-human clinical results of the Quantitative Ultrashort Time-to-Echo Contrast Enhanced (QUTE-CE) MRA technique using the superparamagnetic iron oxide nanoparticle agent ferumoxytol for vascular imaging of the head/brain in 15 subjects at 3.0T. The QUTE-CE MRA method was implemented on a 3T scanner using a stack-of-spirals 3D Ultrashort Time-to-Echo sequence. Time-of-flight MRA and standard TE T1-weighted (T1w) images were also collected. For comparison, gadolinium-enhanced blood pool phase images were obtained retrospectively from clinical practice. Signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and intraluminal signal heterogeneity (ISH) were assessed and compared across approaches with Welch’s two-sided t-test. Results. Fifteen volunteers (54±17 years old, 9 women) participated. QUTE-CE MRA provided high-contrast snapshots of the arterial and venous networks with lower intraluminal heterogeneity. QUTE-CE demonstrated significantly higher SNR (1707±226), blood-tissue CNR (1447±189), and lower ISH (0.091±0.031) compared to ferumoxytol T1-weighted (551±171; 319±144; 0.186±0.066, respectively) and time-of-flight (343±104; 269±82; 0.190±0.016, respectively), with p<0.001 in each comparison. The high CNR increased the depth of vessel visualization. Vessel lumina were captured with lower heterogeneity. Conclusion. Quantitative Ultrashort Time-to-Echo Contrast-Enhanced MR angiography provides approximately 5-fold superior contrast with fewer artifacts compared to other contrast-enhanced vascular imaging techniques using ferumoxytol or gadolinium, and to noncontrast time-of-flight MR angiography, for clinical vascular imaging. This trial is registered with NCT03266848. |
| format | Article |
| id | doaj-art-c4ef611ae23e44d3ab1167d0f828c2db |
| institution | Kabale University |
| issn | 1687-4196 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomedical Imaging |
| spelling | doaj-art-c4ef611ae23e44d3ab1167d0f828c2db2025-02-03T01:29:25ZengWileyInternational Journal of Biomedical Imaging1687-41962024-01-01202410.1155/2024/9763364Super High Contrast USPIO-Enhanced Cerebrovascular Angiography Using Ultrashort Time-to-Echo MRILiam Timms0Tianyi Zhou1Ju Qiao2Codi Gharagouzloo3Vishala Mishra4Rita Maria Lahoud5John W. Chen6Mukesh Harisinghani7Srinivas Sridhar8Department of PhysicsDepartment of PhysicsDepartment of Mechanical and Industrial EngineeringGordon Center for Medical ImagingDepartment of RadiologyDepartment of RadiologyDepartment of RadiologyDepartment of RadiologyDepartment of PhysicsBackground. Ferumoxytol (Ferahame, AMAG Pharmaceuticals, Waltham, MA) is increasingly used off-label as an MR contrast agent due to its relaxivity and safety profiles. However, its potent T2∗ relaxivity limits achievable T1-weighted positive contrast and leads to artifacts in standard MRI protocols. Optimization of protocols for ferumoxytol deployment is necessary to realize its potential. Methods. We present first-in-human clinical results of the Quantitative Ultrashort Time-to-Echo Contrast Enhanced (QUTE-CE) MRA technique using the superparamagnetic iron oxide nanoparticle agent ferumoxytol for vascular imaging of the head/brain in 15 subjects at 3.0T. The QUTE-CE MRA method was implemented on a 3T scanner using a stack-of-spirals 3D Ultrashort Time-to-Echo sequence. Time-of-flight MRA and standard TE T1-weighted (T1w) images were also collected. For comparison, gadolinium-enhanced blood pool phase images were obtained retrospectively from clinical practice. Signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and intraluminal signal heterogeneity (ISH) were assessed and compared across approaches with Welch’s two-sided t-test. Results. Fifteen volunteers (54±17 years old, 9 women) participated. QUTE-CE MRA provided high-contrast snapshots of the arterial and venous networks with lower intraluminal heterogeneity. QUTE-CE demonstrated significantly higher SNR (1707±226), blood-tissue CNR (1447±189), and lower ISH (0.091±0.031) compared to ferumoxytol T1-weighted (551±171; 319±144; 0.186±0.066, respectively) and time-of-flight (343±104; 269±82; 0.190±0.016, respectively), with p<0.001 in each comparison. The high CNR increased the depth of vessel visualization. Vessel lumina were captured with lower heterogeneity. Conclusion. Quantitative Ultrashort Time-to-Echo Contrast-Enhanced MR angiography provides approximately 5-fold superior contrast with fewer artifacts compared to other contrast-enhanced vascular imaging techniques using ferumoxytol or gadolinium, and to noncontrast time-of-flight MR angiography, for clinical vascular imaging. This trial is registered with NCT03266848.http://dx.doi.org/10.1155/2024/9763364 |
| spellingShingle | Liam Timms Tianyi Zhou Ju Qiao Codi Gharagouzloo Vishala Mishra Rita Maria Lahoud John W. Chen Mukesh Harisinghani Srinivas Sridhar Super High Contrast USPIO-Enhanced Cerebrovascular Angiography Using Ultrashort Time-to-Echo MRI International Journal of Biomedical Imaging |
| title | Super High Contrast USPIO-Enhanced Cerebrovascular Angiography Using Ultrashort Time-to-Echo MRI |
| title_full | Super High Contrast USPIO-Enhanced Cerebrovascular Angiography Using Ultrashort Time-to-Echo MRI |
| title_fullStr | Super High Contrast USPIO-Enhanced Cerebrovascular Angiography Using Ultrashort Time-to-Echo MRI |
| title_full_unstemmed | Super High Contrast USPIO-Enhanced Cerebrovascular Angiography Using Ultrashort Time-to-Echo MRI |
| title_short | Super High Contrast USPIO-Enhanced Cerebrovascular Angiography Using Ultrashort Time-to-Echo MRI |
| title_sort | super high contrast uspio enhanced cerebrovascular angiography using ultrashort time to echo mri |
| url | http://dx.doi.org/10.1155/2024/9763364 |
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