Chemical Targeting of the ATXN1 aa99–163 Interaction Site Suppresses polyQ-Expanded Protein Dimerization
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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American Chemical Society
2025-06-01
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| Series: | ACS Omega |
| Online Access: | https://doi.org/10.1021/acsomega.5c02465 |
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| author | Ioannis Gkekas Katerina Pliatsika Stelios Mylonas Sotirios Katsamakas Apostolos Axenopoulos Simona Kostova Erich E. Wanker Dimitra Hadjipavlou-Litina Konstantinos Xanthopoulos Petros Daras Spyros Petrakis |
| author_facet | Ioannis Gkekas Katerina Pliatsika Stelios Mylonas Sotirios Katsamakas Apostolos Axenopoulos Simona Kostova Erich E. Wanker Dimitra Hadjipavlou-Litina Konstantinos Xanthopoulos Petros Daras Spyros Petrakis |
| author_sort | Ioannis Gkekas |
| collection | DOAJ |
| format | Article |
| id | doaj-art-c4ca45a89dfa4e048df1cfd42d6f26d1 |
| institution | Kabale University |
| issn | 2470-1343 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | American Chemical Society |
| record_format | Article |
| series | ACS Omega |
| spelling | doaj-art-c4ca45a89dfa4e048df1cfd42d6f26d12025-08-20T03:29:07ZengAmerican Chemical SocietyACS Omega2470-13432025-06-011025271942720510.1021/acsomega.5c02465Chemical Targeting of the ATXN1 aa99–163 Interaction Site Suppresses polyQ-Expanded Protein DimerizationIoannis Gkekas0Katerina Pliatsika1Stelios Mylonas2Sotirios Katsamakas3Apostolos Axenopoulos4Simona Kostova5Erich E. Wanker6Dimitra Hadjipavlou-Litina7Konstantinos Xanthopoulos8Petros Daras9Spyros Petrakis10Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, GreeceInstitute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, GreeceInformation Technologies Institute, Centre for Research and Technology Hellas, Thessaloniki, GreeceLaboratory of Pharmaceutical Chemistry, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, GreeceInformation Technologies Institute, Centre for Research and Technology Hellas, Thessaloniki, GreeceMax-Delbrueck-Center for Molecular Medicine in the Helmholtz Association, Berlin, GermanyMax-Delbrueck-Center for Molecular Medicine in the Helmholtz Association, Berlin, GermanyLaboratory of Pharmaceutical Chemistry, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, GreeceInstitute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, GreeceInformation Technologies Institute, Centre for Research and Technology Hellas, Thessaloniki, GreeceInstitute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greecehttps://doi.org/10.1021/acsomega.5c02465 |
| spellingShingle | Ioannis Gkekas Katerina Pliatsika Stelios Mylonas Sotirios Katsamakas Apostolos Axenopoulos Simona Kostova Erich E. Wanker Dimitra Hadjipavlou-Litina Konstantinos Xanthopoulos Petros Daras Spyros Petrakis Chemical Targeting of the ATXN1 aa99–163 Interaction Site Suppresses polyQ-Expanded Protein Dimerization ACS Omega |
| title | Chemical Targeting of the ATXN1 aa99–163 Interaction Site Suppresses polyQ-Expanded Protein Dimerization |
| title_full | Chemical Targeting of the ATXN1 aa99–163 Interaction Site Suppresses polyQ-Expanded Protein Dimerization |
| title_fullStr | Chemical Targeting of the ATXN1 aa99–163 Interaction Site Suppresses polyQ-Expanded Protein Dimerization |
| title_full_unstemmed | Chemical Targeting of the ATXN1 aa99–163 Interaction Site Suppresses polyQ-Expanded Protein Dimerization |
| title_short | Chemical Targeting of the ATXN1 aa99–163 Interaction Site Suppresses polyQ-Expanded Protein Dimerization |
| title_sort | chemical targeting of the atxn1 aa99 163 interaction site suppresses polyq expanded protein dimerization |
| url | https://doi.org/10.1021/acsomega.5c02465 |
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