Multifactorial analysis of radiochemical purity in high-activity 177Lu-labeled theranostics: impact of precursor source, 177Lu form, and production parameters

Multifactorial analysis of radiochemical purity in high-activity 177Lu-labeled theranostics: impact of precursor source, 177Lu form, and production parameters

Abstract Background Lutetium-177 (177Lu) theranostics have revolutionized personalized cancer treatment, particularly with FDA-approved therapies like [177Lu]Lu-DOTA-TATE for neuroendocrine tumors and [177Lu]Lu-PSMA for prostate cancer. Despite growing clinical adoption, there is limited understandi...

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Bibliographic Details
Main Authors: William Hunt, Mathew Long, Usama Kamil, Sunil Kellapatha, Wayne Noonan, Peter D. Roselt, Nathan Papa, Brittany Emmerson, Michael S. Hofman, Mohammad B. Haskali
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Lutetium-177 theranostics
Radiochemical purity
High-activity production
Carrier-added lutetium-177
Non-carrier-added lutetium-177
DOTATATE
Online Access:https://doi.org/10.1186/s41181-025-00372-5
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https://doi.org/10.1186/s41181-025-00372-5

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