A 3D human iPSC-derived multi-cell type neurosphere system to model cellular responses to chronic amyloidosis

A 3D human iPSC-derived multi-cell type neurosphere system to model cellular responses to chronic amyloidosis

Abstract Background Alzheimer’s disease (AD) is characterized by progressive amyloid beta (Aβ) deposition in the brain, with eventual widespread neurodegeneration. While the cell-specific molecular signature of end-stage AD is reasonably well characterized through autopsy material, less is known abo...

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Main Authors: Stefan Wendt, Ada J. Lin, Sarah N. Ebert, Declan J. Brennan, Wenji Cai, Yanyang Bai, Da Young Kong, Stefano Sorrentino, Christopher J. Groten, Christopher Lee, Jonathan Frew, Hyun B. Choi, Konstantina Karamboulas, Mathias Delhaye, Ian R. Mackenzie, David R. Kaplan, Freda D. Miller, Brian A. MacVicar, Haakon B. Nygaard
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-025-03433-3
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