Region-informed machine learning model for choroid plexus segmentation in Alzheimer’s disease

Region-informed machine learning model for choroid plexus segmentation in Alzheimer’s disease

IntroductionThe choroid plexus (CP), a critical structure for cerebrospinal fluid (CSF) production, has been increasingly recognized for its involvement in Alzheimer’s disease (AD). Accurate segmentation of CP from magnetic resonance imaging (MRI) remains challenging due to its irregular shape, vari...

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Bibliographic Details
Main Authors: Liangdong Zhou, Tracy A. Butler, Xiuyuan H. Wang, Samantha A. Keil, Seyed Hani Hojjati, Tsung-Wei Hu, Mélissa Savard, Firoza Z. Lussier, Pedro Rosa-Neto, Lidia Glodzik, Mony J. de Leon, Gloria C. Chiang, Yi Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
choroid plexus
Alzheimer’s disease
cerebrospinal fluid
neurofluids
brain clearance
Gaussian mixture model
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1613320/full
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