Targeted high-level production of chuangxinmycin and its halogenated derivatives with antitubercular activity

Targeted high-level production of chuangxinmycin and its halogenated derivatives with antitubercular activity

Abstract Background Chuangxinmycin (CM) is an old antibiotic from Actinoplanes tsinanensis CPCC, 200056, characterized by a dihydrothiopyrano[4,3,2-cd]indole scaffold and potent activity against Mycobacterium tuberculosis. Its congener norchuangxinmycin (NCM), which lacks antibacterial activity agai...

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Bibliographic Details
Main Authors: Xiongfang Zhao, Yuan Lu, Xintong Zhang, Xiumin Zhang, Yu Du, Xingli Han, Yuting Zhu, Wei Yu, Linzhuan Wu, Xingxing Li, Yuanyuan Shi, Tianyu Zhang, Bin Hong
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Microbial Cell Factories
Subjects:
Mycobacterium tuberculosis
Chuangxinmycin
High-level production
Halogenated derivatives
Online Access:https://doi.org/10.1186/s12934-025-02740-x
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https://doi.org/10.1186/s12934-025-02740-x

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