Accelerated epigenetic aging in Huntington’s disease involves polycomb repressive complex 1

Accelerated epigenetic aging in Huntington’s disease involves polycomb repressive complex 1

Abstract Loss of epigenetic information during physiological aging compromises cellular identity, leading to de-repression of developmental genes. Here, we assessed the epigenomic landscape of vulnerable neurons in two reference mouse models of Huntington neurodegenerative disease (HD), using cell-t...

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Main Authors: Baptiste Brulé, Rafael Alcalá-Vida, Noémie Penaud, Jil Scuto, Coline Mounier, Jonathan Seguin, Sina Vincent Khodaverdian, Brigitte Cosquer, Etienne Birmelé, Stéphanie Le Gras, Charles Decraene, Anne-Laurence Boutillier, Karine Merienne
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56722-z
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https://doi.org/10.1038/s41467-025-56722-z

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