The hypoglycemic potential of phenolics from functional foods and their mechanisms
Long-term postprandial hyperglycemia is a primary risk factor for developing chronic metabolic diseases such as obesity, type 2 diabetes, and cardiovascular disease. Chronic hyperglycemia induces the glycation of proteins, oxidative stress, inflammation and increases plasma insulin and lipid concent...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-07-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022002397 |
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| author | Oksana Golovinskaia Chin-Kun Wang |
| author_facet | Oksana Golovinskaia Chin-Kun Wang |
| author_sort | Oksana Golovinskaia |
| collection | DOAJ |
| description | Long-term postprandial hyperglycemia is a primary risk factor for developing chronic metabolic diseases such as obesity, type 2 diabetes, and cardiovascular disease. Chronic hyperglycemia induces the glycation of proteins, oxidative stress, inflammation and increases plasma insulin and lipid concentrations. Insulin resistance is the primary cause of postprandial excursions of blood glucose and lipids. Hyperglycemia can be treated by lowering dietary carbohydrates intake, digestion, and absorption. Various functional foods improve glucose metabolism by increasing insulin sensitivity and inhibiting α-glucosidase in the small intestine. Natural phytochemicals, especially active phenolics are good antioxidants and show anti-inflammatory action and regulate blood glucose. This review aimed to report on hypoglycemic properties of active phenolics from functional foods and their proposed anti-diabetic mechanisms. Nevertheless, further clinical trials are required to confirm the bioavailability, safety, and efficacy of phenolics, especially the dosage and duration of treatment, to avoid adverse effects and give better dietary recommendations. |
| format | Article |
| id | doaj-art-c44c6c8c71754ac5987962fe85baa323 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-c44c6c8c71754ac5987962fe85baa3232025-02-03T11:09:29ZengTsinghua University PressFood Science and Human Wellness2213-45302023-07-011249861007The hypoglycemic potential of phenolics from functional foods and their mechanismsOksana Golovinskaia0Chin-Kun Wang1Department of Nutrition, Chung Shan Medical University, Taiwan, ChinaCorresponding author at: Department of Nutrition, Chung Shan Medical University, Taiwan 405, China.; Department of Nutrition, Chung Shan Medical University, Taiwan, ChinaLong-term postprandial hyperglycemia is a primary risk factor for developing chronic metabolic diseases such as obesity, type 2 diabetes, and cardiovascular disease. Chronic hyperglycemia induces the glycation of proteins, oxidative stress, inflammation and increases plasma insulin and lipid concentrations. Insulin resistance is the primary cause of postprandial excursions of blood glucose and lipids. Hyperglycemia can be treated by lowering dietary carbohydrates intake, digestion, and absorption. Various functional foods improve glucose metabolism by increasing insulin sensitivity and inhibiting α-glucosidase in the small intestine. Natural phytochemicals, especially active phenolics are good antioxidants and show anti-inflammatory action and regulate blood glucose. This review aimed to report on hypoglycemic properties of active phenolics from functional foods and their proposed anti-diabetic mechanisms. Nevertheless, further clinical trials are required to confirm the bioavailability, safety, and efficacy of phenolics, especially the dosage and duration of treatment, to avoid adverse effects and give better dietary recommendations.http://www.sciencedirect.com/science/article/pii/S2213453022002397PhenolicsFunctional foodsHypoglycemiaInsulin resistanceInsulin secretion |
| spellingShingle | Oksana Golovinskaia Chin-Kun Wang The hypoglycemic potential of phenolics from functional foods and their mechanisms Food Science and Human Wellness Phenolics Functional foods Hypoglycemia Insulin resistance Insulin secretion |
| title | The hypoglycemic potential of phenolics from functional foods and their mechanisms |
| title_full | The hypoglycemic potential of phenolics from functional foods and their mechanisms |
| title_fullStr | The hypoglycemic potential of phenolics from functional foods and their mechanisms |
| title_full_unstemmed | The hypoglycemic potential of phenolics from functional foods and their mechanisms |
| title_short | The hypoglycemic potential of phenolics from functional foods and their mechanisms |
| title_sort | hypoglycemic potential of phenolics from functional foods and their mechanisms |
| topic | Phenolics Functional foods Hypoglycemia Insulin resistance Insulin secretion |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022002397 |
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