Multi-omic integration of single-cell data uncovers methylation profiles of super-enhancers in skeletal muscle stem cells

Multi-omic integration of single-cell data uncovers methylation profiles of super-enhancers in skeletal muscle stem cells

Abstract Introduction Skeletal muscle stem cells (MuSCs) have strong regenerative abilities, but as we age, their ability to regenerate decreases, leading to a decline in muscle function. Although the methylation reprogramming of super-enhancers (SEs) plays a pivotal role in regulating gene expressi...

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Bibliographic Details
Main Authors: Anyu Zeng, Hailong Liu, Shuling He, Xuming Luo, Zhiqi Zhang, Ming Fu, Baoxi Yu
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Epigenetics & Chromatin
Subjects:
Super-enhancer
Methylation reprogramming
Skeletal muscle stem cell
Aging
Online Access:https://doi.org/10.1186/s13072-025-00619-0
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https://doi.org/10.1186/s13072-025-00619-0

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