The Impact of COVID-19 on Clinical Outcomes in Patients With Traumatic Brain Injury
Background: Traumatic brain injury (TBI) is a leading cause of mortality and morbidity worldwide. COVID-19 can impact the central nervous system (CNS) and hematologic system and appears to affect clinical outcomes and the average cerebral hemorrhage volume (ACHV) in patients with TBI. Objectives: Ou...
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| Format: | Article |
| Language: | English |
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Guilan University of Medical Sciences
2025-01-01
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| Series: | Caspian Journal of Neurological Sciences |
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| Online Access: | http://cjns.gums.ac.ir/article-1-767-en.pdf |
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| author | Farnaz Mahdavi Sima Fallah-Arzpeima Zoheir Reihanian Khatereh Asadi Nooshin Zaresharifi Roghaye Zare Mohammad Ali Yazdanipour Masoud Shabani Chobe |
| author_facet | Farnaz Mahdavi Sima Fallah-Arzpeima Zoheir Reihanian Khatereh Asadi Nooshin Zaresharifi Roghaye Zare Mohammad Ali Yazdanipour Masoud Shabani Chobe |
| author_sort | Farnaz Mahdavi |
| collection | DOAJ |
| description | Background: Traumatic brain injury (TBI) is a leading cause of mortality and morbidity worldwide. COVID-19 can impact the central nervous system (CNS) and hematologic system and appears to affect clinical outcomes and the average cerebral hemorrhage volume (ACHV) in patients with TBI.
Objectives: Our study focused on evaluating the effects of COVID-19 on clinical outcomes and the ACHV in TBI patients.
Materials & Methods: In this study, we included TBI patients presenting to an academic trauma center in the North of Iran and categorized them into two groups: infected with COVID-19 and non-infected. A total of 128 TBI patients were identified during 19 months of the COVID-19 pandemic.
Results: Road accidents account for 92.2% of TBI. Among different types of brain lesions, subdural hematoma (SDH) had a significant relationship with COVID-19 (P=0.043). Among patients, 13 (10.2%) were on anticoagulants, with no significant differences between the two groups. Among the COVID-19 patients, those who were anticoagulant users experienced a higher ACHV than those who did not use this medication (P=0.015). The two groups had no significant difference in the ACHV and mortality (P=0.758, P=0.601, respectively). The regression analysis indicates no statistically significant relationship between COVID-19 and ACHV (P=0.983) or between COVID-19 and the mortality rate of TBI patients (P=0.695).
Conclusion: The study highlights that TBI patients with COVID-19 on anticoagulants show higher ACHV levels than those without, a pattern missing in non-COVID patients. This finding suggests a possible synergistic interaction between COVID-19 and anticoagulation, with COVID-19 potentially worsening coagulation disorders. |
| format | Article |
| id | doaj-art-c439fbd3cac9442f842330a08a8b12e9 |
| institution | Kabale University |
| issn | 2423-4818 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Guilan University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Neurological Sciences |
| spelling | doaj-art-c439fbd3cac9442f842330a08a8b12e92025-02-04T11:29:02ZengGuilan University of Medical SciencesCaspian Journal of Neurological Sciences2423-48182025-01-011115866The Impact of COVID-19 on Clinical Outcomes in Patients With Traumatic Brain InjuryFarnaz Mahdavi0Sima Fallah-Arzpeima1Zoheir Reihanian2Khatereh Asadi3Nooshin Zaresharifi4Roghaye Zare5Mohammad Ali Yazdanipour6Masoud Shabani Chobe7 School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Department of Radiology, School of Medicine, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran. Department of Neurosurgery, School of Medicine, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran. Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Pathology, School of Medicine, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran. Trauma Institute, Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran. Trauma Institute, Neuroscience Research Center, Guilan University of Medical Sciences, Rasht, Iran. Trauma Institute, Neuroscience Research Center, Guilan University of Medical Sciences, Rasht, Iran. Background: Traumatic brain injury (TBI) is a leading cause of mortality and morbidity worldwide. COVID-19 can impact the central nervous system (CNS) and hematologic system and appears to affect clinical outcomes and the average cerebral hemorrhage volume (ACHV) in patients with TBI. Objectives: Our study focused on evaluating the effects of COVID-19 on clinical outcomes and the ACHV in TBI patients. Materials & Methods: In this study, we included TBI patients presenting to an academic trauma center in the North of Iran and categorized them into two groups: infected with COVID-19 and non-infected. A total of 128 TBI patients were identified during 19 months of the COVID-19 pandemic. Results: Road accidents account for 92.2% of TBI. Among different types of brain lesions, subdural hematoma (SDH) had a significant relationship with COVID-19 (P=0.043). Among patients, 13 (10.2%) were on anticoagulants, with no significant differences between the two groups. Among the COVID-19 patients, those who were anticoagulant users experienced a higher ACHV than those who did not use this medication (P=0.015). The two groups had no significant difference in the ACHV and mortality (P=0.758, P=0.601, respectively). The regression analysis indicates no statistically significant relationship between COVID-19 and ACHV (P=0.983) or between COVID-19 and the mortality rate of TBI patients (P=0.695). Conclusion: The study highlights that TBI patients with COVID-19 on anticoagulants show higher ACHV levels than those without, a pattern missing in non-COVID patients. This finding suggests a possible synergistic interaction between COVID-19 and anticoagulation, with COVID-19 potentially worsening coagulation disorders.http://cjns.gums.ac.ir/article-1-767-en.pdfbrain injurytraumaticcovid-19cerebral hemorrhages |
| spellingShingle | Farnaz Mahdavi Sima Fallah-Arzpeima Zoheir Reihanian Khatereh Asadi Nooshin Zaresharifi Roghaye Zare Mohammad Ali Yazdanipour Masoud Shabani Chobe The Impact of COVID-19 on Clinical Outcomes in Patients With Traumatic Brain Injury Caspian Journal of Neurological Sciences brain injury traumatic covid-19 cerebral hemorrhages |
| title | The Impact of COVID-19 on Clinical Outcomes in Patients With Traumatic Brain Injury |
| title_full | The Impact of COVID-19 on Clinical Outcomes in Patients With Traumatic Brain Injury |
| title_fullStr | The Impact of COVID-19 on Clinical Outcomes in Patients With Traumatic Brain Injury |
| title_full_unstemmed | The Impact of COVID-19 on Clinical Outcomes in Patients With Traumatic Brain Injury |
| title_short | The Impact of COVID-19 on Clinical Outcomes in Patients With Traumatic Brain Injury |
| title_sort | impact of covid 19 on clinical outcomes in patients with traumatic brain injury |
| topic | brain injury traumatic covid-19 cerebral hemorrhages |
| url | http://cjns.gums.ac.ir/article-1-767-en.pdf |
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