Da-Yuan-Yin decoction suppresses NETs formation, inhibits the IL-23/JAK2/STAT3 signalling pathway, and modulates metabolic profiles and gut microbiota composition in damp-heat syndrome

Da-Yuan-Yin decoction suppresses NETs formation, inhibits the IL-23/JAK2/STAT3 signalling pathway, and modulates metabolic profiles and gut microbiota composition in damp-heat syndrome

Background Da-Yuan-Yin Decoction (DYY), used since the early Qing Dynasty in China for damp-heat syndrome, was evaluated for its comprehensive protective effects.Materials and methods Rats received a high-fat/high-sugar diet for 14 days, then daily exposure to high temperature/humidity (31.0 ± 0.5°C...

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Bibliographic Details
Main Authors: Yun Yang, Lengqiu Guo, Jinghua Yu, Wei Peng, Qi Wang, Lan Wei, Xihua Chen, Chunyan Min, Xiaogang Jiang, Song Zhu, Haixin Zhao, Zhenyu Xuan, Jianzhong Yu, Jian Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Annals of Medicine
Subjects:
Da-Yuan-Yin decoction
damp-heat syndrome
neutrophil extracellular traps
faecal metabolites
gut microbiota
inflammation
Online Access:https://www.tandfonline.com/doi/10.1080/07853890.2025.2519684
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https://www.tandfonline.com/doi/10.1080/07853890.2025.2519684

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