Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors

Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors

Abstract Background Atypical teratoid rhabdoid tumors (ATRT) are incurable high-grade pediatric brain tumors. Despite intensive research efforts, the prognosis for ATRT patients under currently established treatment protocols is poor. While novel therapeutic strategies are urgently needed, the gener...

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Main Authors: Daniel J. Merk, Foteini Tsiami, Sophie Hirsch, Bianca Walter, Lara A. Haeusser, Jens D. Maile, Aaron Stahl, Mohamed A. Jarboui, Anna Lechado-Terradas, Franziska Klose, Sepideh Babaei, Jakob Admard, Nicolas Casadei, Cristiana Roggia, Michael Spohn, Jens Schittenhelm, Stephan Singer, Ulrich Schüller, Federica Piccioni, Nicole S. Persky, Manfred Claassen, Marcos Tatagiba, Philipp J. Kahle, David E. Root, Markus Templin, Ghazaleh Tabatabai
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Genome Biology
Subjects:
Functional screening
CRISPR-Cas9
Genetic dependencies
Rhabdoid tumors
CDK4/6 inhibitors
AMBRA1
Online Access:https://doi.org/10.1186/s13059-024-03438-w
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https://doi.org/10.1186/s13059-024-03438-w

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