Narirutin mitigates inflammatory arthritis and osteoporosis through modulating macrophage phenotype and osteoclastogenesis

Narirutin mitigates inflammatory arthritis and osteoporosis through modulating macrophage phenotype and osteoclastogenesis

Background: Inflammatory arthritis (IA), exemplified by rheumatoid arthritis (RA), represents a prevalent autoimmune-driven inflammatory bone disorder hallmarked by chronic synovitis and progressive bone erosion, culminating in joint dysfunction and systemic osteoporosis. Narirutin (NRT), a flavonoi...

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Bibliographic Details
Main Authors: Qing Wang, Xiaole Peng, Hao Xu, Yuhu Zhao, Xiaoheng Lu, Chengyao Lu, Qihan Wang, Wei Lu, Qifeng Sheng, Xiaomin Lu, Yaozeng Xu, Dechun Geng
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Journal of Orthopaedic Translation
Subjects:
Inflammatory arthritis
Narirutin
Osteoporosis
Macrophage polarization
Osteoclast
Osteoimmunomodulatory
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X25001214
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