In Vitro Evaluation of Antipseudomonal Activity and Safety Profile of Peptidomimetic Furin Inhibitors

In Vitro Evaluation of Antipseudomonal Activity and Safety Profile of Peptidomimetic Furin Inhibitors

Inhibitors of the serine protease furin have been widely studied as antimicrobial agents due to their ability to block the cleavage and activation of certain viral surface proteins and bacterial toxins. In this study, the antipseudomonal effects and safety profiles of the furin inhibitors MI-1851 an...

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Bibliographic Details
Main Authors: Sara Maluck, Rivka Bobrovsky, Miklós Poór, Roman W. Lange, Torsten Steinmetzer, Ákos Jerzsele, András Adorján, Dávid Bajusz, Anita Rácz, Erzsébet Pászti-Gere
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Biomedicines
Subjects:
furin inhibitors
protein binding
oxidative stress
porcine intestinal cells
hepatocytes
cytochrome P450 3A4
Online Access:https://www.mdpi.com/2227-9059/12/9/2075
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https://www.mdpi.com/2227-9059/12/9/2075

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