The Mechanosensory Role of Primary Cilia in Vascular Hypertension
Local regulation of vascular tone plays an important role in cardiovascular control of blood pressure. Aside from chemical or hormonal regulations, this local homeostasis is highly regulated by fluid-shear stress. It was previously unclear how vascular endothelial cells were able to sense fluid-shea...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/376281 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558892570116096 |
|---|---|
| author | Surya M. Nauli Xingjian Jin Beerend P. Hierck |
| author_facet | Surya M. Nauli Xingjian Jin Beerend P. Hierck |
| author_sort | Surya M. Nauli |
| collection | DOAJ |
| description | Local regulation of vascular tone plays an important role in cardiovascular control of blood pressure. Aside from chemical or hormonal regulations, this local homeostasis is highly regulated by fluid-shear stress. It was previously unclear how vascular endothelial cells were able to sense fluid-shear stress. The cellular functions of mechanosensory cilia within vascular system have emerged recently. In particular, hypertension is insidious and remains a continuous problem that evolves during the course of polycystic kidney disease (PKD). The basic and clinical perspectives on primary cilia are discussed with regard to the pathogenesis of hypertension in PKD. |
| format | Article |
| id | doaj-art-c3d3dbce81b34569a15c76ae2c7532a9 |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-c3d3dbce81b34569a15c76ae2c7532a92025-02-03T01:31:18ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322011-01-01201110.1155/2011/376281376281The Mechanosensory Role of Primary Cilia in Vascular HypertensionSurya M. Nauli0Xingjian Jin1Beerend P. Hierck2Colleges of Medicine, Pharmacy and Pharmaceutical Sciences, The University of Toledo, Health Science Campus, HEB 274, 3000 Arlington Avenue MS 1015, Toledo, OH 43614, USAColleges of Medicine, Pharmacy and Pharmaceutical Sciences, The University of Toledo, Health Science Campus, HEB 274, 3000 Arlington Avenue MS 1015, Toledo, OH 43614, USADepartment of Anatomy and Embryology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The NetherlandsLocal regulation of vascular tone plays an important role in cardiovascular control of blood pressure. Aside from chemical or hormonal regulations, this local homeostasis is highly regulated by fluid-shear stress. It was previously unclear how vascular endothelial cells were able to sense fluid-shear stress. The cellular functions of mechanosensory cilia within vascular system have emerged recently. In particular, hypertension is insidious and remains a continuous problem that evolves during the course of polycystic kidney disease (PKD). The basic and clinical perspectives on primary cilia are discussed with regard to the pathogenesis of hypertension in PKD.http://dx.doi.org/10.1155/2011/376281 |
| spellingShingle | Surya M. Nauli Xingjian Jin Beerend P. Hierck The Mechanosensory Role of Primary Cilia in Vascular Hypertension International Journal of Vascular Medicine |
| title | The Mechanosensory Role of Primary Cilia in Vascular Hypertension |
| title_full | The Mechanosensory Role of Primary Cilia in Vascular Hypertension |
| title_fullStr | The Mechanosensory Role of Primary Cilia in Vascular Hypertension |
| title_full_unstemmed | The Mechanosensory Role of Primary Cilia in Vascular Hypertension |
| title_short | The Mechanosensory Role of Primary Cilia in Vascular Hypertension |
| title_sort | mechanosensory role of primary cilia in vascular hypertension |
| url | http://dx.doi.org/10.1155/2011/376281 |
| work_keys_str_mv | AT suryamnauli themechanosensoryroleofprimaryciliainvascularhypertension AT xingjianjin themechanosensoryroleofprimaryciliainvascularhypertension AT beerendphierck themechanosensoryroleofprimaryciliainvascularhypertension AT suryamnauli mechanosensoryroleofprimaryciliainvascularhypertension AT xingjianjin mechanosensoryroleofprimaryciliainvascularhypertension AT beerendphierck mechanosensoryroleofprimaryciliainvascularhypertension |