Klebsiella pneumoniae evolution in the gut leads to spontaneous capsule loss and decreased virulence potential

Klebsiella pneumoniae evolution in the gut leads to spontaneous capsule loss and decreased virulence potential

ABSTRACT Klebsiella pneumoniae (Kp) is an opportunistic pathogen that poses a major threat in healthcare settings. The gut is a primary Kp reservoir in hospitalized patients, and colonization is a major risk factor for Kp infection. The stability of virulence determinants such as capsule and lipopol...

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Main Authors: Lavinia V. Unverdorben, Ali Pirani, Kyle Gontjes, Bridget Moricz, Caitlyn L. Holmes, Evan S. Snitkin, Michael A. Bachman
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mBio
Subjects:
Klebsiella
intestinal colonization
capsule
evolution
mobile genetic elements
lipopolysaccharide
Online Access:https://journals.asm.org/doi/10.1128/mbio.02362-24
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https://journals.asm.org/doi/10.1128/mbio.02362-24

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