The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis
Allergic conjunctivitis (AC) is a common allergic disease that is often associated with the onset of rhinitis or asthma. The incidence of AC has increased significantly in recent years possibly due to air pollution and climate warming. AC seriously affects patients’ quality of life and work efficien...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2020/6917185 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556915012403200 |
|---|---|
| author | Xiang-Tian Meng Yun-Yue Shi Hong Zhang Hong-Yan Zhou |
| author_facet | Xiang-Tian Meng Yun-Yue Shi Hong Zhang Hong-Yan Zhou |
| author_sort | Xiang-Tian Meng |
| collection | DOAJ |
| description | Allergic conjunctivitis (AC) is a common allergic disease that is often associated with the onset of rhinitis or asthma. The incidence of AC has increased significantly in recent years possibly due to air pollution and climate warming. AC seriously affects patients’ quality of life and work efficiency. Th (T-helper) 2 immune responses and type I hypersensitivity reactions are generally considered the basis of occurrence of AC. It has been found that new subpopulations of T-helper cells, Th17 cells that produce interleukin-17 (IL-17), play an important role in the Th2-mediated pathogenesis of conjunctivitis. Studies have shown that Th17 cells are involved in a variety of immune inflammation, including psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma. However, the role of Th17 and IL-17 in AC is unclear. This paper will focus on how T-helper 17 cells and interleukin-17 are activated in the Th2 immune response of allergic conjunctivitis and how they promote the Th2 immune response of AC. |
| format | Article |
| id | doaj-art-c3caa40cb8c749b5bf2f8804c191143a |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-c3caa40cb8c749b5bf2f8804c191143a2025-02-03T05:44:13ZengWileyJournal of Ophthalmology2090-004X2090-00582020-01-01202010.1155/2020/69171856917185The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic ConjunctivitisXiang-Tian Meng0Yun-Yue Shi1Hong Zhang2Hong-Yan Zhou3Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, ChinaDepartment of Obstetrics and Gynecology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, ChinaDepartment of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, ChinaDepartment of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, ChinaAllergic conjunctivitis (AC) is a common allergic disease that is often associated with the onset of rhinitis or asthma. The incidence of AC has increased significantly in recent years possibly due to air pollution and climate warming. AC seriously affects patients’ quality of life and work efficiency. Th (T-helper) 2 immune responses and type I hypersensitivity reactions are generally considered the basis of occurrence of AC. It has been found that new subpopulations of T-helper cells, Th17 cells that produce interleukin-17 (IL-17), play an important role in the Th2-mediated pathogenesis of conjunctivitis. Studies have shown that Th17 cells are involved in a variety of immune inflammation, including psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma. However, the role of Th17 and IL-17 in AC is unclear. This paper will focus on how T-helper 17 cells and interleukin-17 are activated in the Th2 immune response of allergic conjunctivitis and how they promote the Th2 immune response of AC.http://dx.doi.org/10.1155/2020/6917185 |
| spellingShingle | Xiang-Tian Meng Yun-Yue Shi Hong Zhang Hong-Yan Zhou The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis Journal of Ophthalmology |
| title | The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis |
| title_full | The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis |
| title_fullStr | The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis |
| title_full_unstemmed | The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis |
| title_short | The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis |
| title_sort | role of th17 cells and il 17 in th2 immune responses of allergic conjunctivitis |
| url | http://dx.doi.org/10.1155/2020/6917185 |
| work_keys_str_mv | AT xiangtianmeng theroleofth17cellsandil17inth2immuneresponsesofallergicconjunctivitis AT yunyueshi theroleofth17cellsandil17inth2immuneresponsesofallergicconjunctivitis AT hongzhang theroleofth17cellsandil17inth2immuneresponsesofallergicconjunctivitis AT hongyanzhou theroleofth17cellsandil17inth2immuneresponsesofallergicconjunctivitis AT xiangtianmeng roleofth17cellsandil17inth2immuneresponsesofallergicconjunctivitis AT yunyueshi roleofth17cellsandil17inth2immuneresponsesofallergicconjunctivitis AT hongzhang roleofth17cellsandil17inth2immuneresponsesofallergicconjunctivitis AT hongyanzhou roleofth17cellsandil17inth2immuneresponsesofallergicconjunctivitis |