Cross Talk between Proliferative, Angiogenic, and Cellular Mechanisms Orchestred by HIF-1α in Psoriasis
Psoriasis is a chronic inflammatory skin disease where the altered regulation in angiogenesis, inflammation, and proliferation of keratinocytes are the possible causes of the disease, and the transcription factor “hypoxia-inducible factor 1-alpha” (HIF-1α) is involved in the homeostasis of these thr...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/607363 |
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| author | Azael Torales-Cardeña Isaí Martínez-Torres Sandra Rodríguez-Martínez Fernando Gómez-Chávez Juan C. Cancino-Díaz Ernesto A. Vázquez-Sánchez Mario E. Cancino-Díaz |
| author_facet | Azael Torales-Cardeña Isaí Martínez-Torres Sandra Rodríguez-Martínez Fernando Gómez-Chávez Juan C. Cancino-Díaz Ernesto A. Vázquez-Sánchez Mario E. Cancino-Díaz |
| author_sort | Azael Torales-Cardeña |
| collection | DOAJ |
| description | Psoriasis is a chronic inflammatory skin disease where the altered regulation in angiogenesis, inflammation, and proliferation of keratinocytes are the possible causes of the disease, and the transcription factor “hypoxia-inducible factor 1-alpha” (HIF-1α) is involved in the homeostasis of these three biological phenomena. In this review, the role of HIF-1α in the cross talk between the cytokines and cells of the immunological system involved in the pathogenesis of psoriasis is discussed. |
| format | Article |
| id | doaj-art-c3b7b83da11543fb8bb11daaf00e31cd |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c3b7b83da11543fb8bb11daaf00e31cd2025-02-03T05:59:22ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/607363607363Cross Talk between Proliferative, Angiogenic, and Cellular Mechanisms Orchestred by HIF-1α in PsoriasisAzael Torales-Cardeña0Isaí Martínez-Torres1Sandra Rodríguez-Martínez2Fernando Gómez-Chávez3Juan C. Cancino-Díaz4Ernesto A. Vázquez-Sánchez5Mario E. Cancino-Díaz6Immunology Department, National School of Biological Sciences, National Polytechnic Institute, Plan de Ayala y Prolongación de Carpio S/N, Colonia Santo Tomás, Miguel Hidalgo, 11340 Mexico City, DF, MexicoImmunology Department, National School of Biological Sciences, National Polytechnic Institute, Plan de Ayala y Prolongación de Carpio S/N, Colonia Santo Tomás, Miguel Hidalgo, 11340 Mexico City, DF, MexicoImmunology Department, National School of Biological Sciences, National Polytechnic Institute, Plan de Ayala y Prolongación de Carpio S/N, Colonia Santo Tomás, Miguel Hidalgo, 11340 Mexico City, DF, MexicoImmunology Department, National School of Biological Sciences, National Polytechnic Institute, Plan de Ayala y Prolongación de Carpio S/N, Colonia Santo Tomás, Miguel Hidalgo, 11340 Mexico City, DF, MexicoMicrobiology Department, National School of Biological Sciences, National Polytechnic Institute, Plan de Ayala y Prolongación de Carpio S/N, Colonia Santo Tomás, Miguel Hidalgo, 11340 Mexico City, DF, MexicoImmunology Department, National School of Biological Sciences, National Polytechnic Institute, Plan de Ayala y Prolongación de Carpio S/N, Colonia Santo Tomás, Miguel Hidalgo, 11340 Mexico City, DF, MexicoImmunology Department, National School of Biological Sciences, National Polytechnic Institute, Plan de Ayala y Prolongación de Carpio S/N, Colonia Santo Tomás, Miguel Hidalgo, 11340 Mexico City, DF, MexicoPsoriasis is a chronic inflammatory skin disease where the altered regulation in angiogenesis, inflammation, and proliferation of keratinocytes are the possible causes of the disease, and the transcription factor “hypoxia-inducible factor 1-alpha” (HIF-1α) is involved in the homeostasis of these three biological phenomena. In this review, the role of HIF-1α in the cross talk between the cytokines and cells of the immunological system involved in the pathogenesis of psoriasis is discussed.http://dx.doi.org/10.1155/2015/607363 |
| spellingShingle | Azael Torales-Cardeña Isaí Martínez-Torres Sandra Rodríguez-Martínez Fernando Gómez-Chávez Juan C. Cancino-Díaz Ernesto A. Vázquez-Sánchez Mario E. Cancino-Díaz Cross Talk between Proliferative, Angiogenic, and Cellular Mechanisms Orchestred by HIF-1α in Psoriasis Mediators of Inflammation |
| title | Cross Talk between Proliferative, Angiogenic, and Cellular Mechanisms Orchestred by HIF-1α in Psoriasis |
| title_full | Cross Talk between Proliferative, Angiogenic, and Cellular Mechanisms Orchestred by HIF-1α in Psoriasis |
| title_fullStr | Cross Talk between Proliferative, Angiogenic, and Cellular Mechanisms Orchestred by HIF-1α in Psoriasis |
| title_full_unstemmed | Cross Talk between Proliferative, Angiogenic, and Cellular Mechanisms Orchestred by HIF-1α in Psoriasis |
| title_short | Cross Talk between Proliferative, Angiogenic, and Cellular Mechanisms Orchestred by HIF-1α in Psoriasis |
| title_sort | cross talk between proliferative angiogenic and cellular mechanisms orchestred by hif 1α in psoriasis |
| url | http://dx.doi.org/10.1155/2015/607363 |
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