Lack of HLH in FMF

Lack of HLH in FMF

Abstract Background Macrophage activation syndrome (MAS) is a severe complication of systemic juvenile idiopathic arthritis (sJIA), driven by excessive activation of T cells and macrophages, resulting in a cytokine storm. IFN-γ and IL-18 play crucial roles, with monocyte and macrophage hyperresponsi...

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Main Authors: Ozge Basaran, Erdal Sag, Elif Arslanoglu Aydın, Busra Aydın, Nur Kübra Tasdemir, Elif Celikel, Yagmur Bayındır, Semanur Özdel, Yelda Bilginer, Alexei A Grom, Seza Ozen
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Pediatric Rheumatology Online Journal
Subjects:
CXCL-9
CXCL-10
Familial Mediterranean fever
IL-18
Macrophage activation syndrome
Online Access:https://doi.org/10.1186/s12969-025-01064-9
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https://doi.org/10.1186/s12969-025-01064-9

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