Unique N-glycosylation signatures in human iPSC derived microglia activated by Aβ oligomer and lipopolysaccharide

Unique N-glycosylation signatures in human iPSC derived microglia activated by Aβ oligomer and lipopolysaccharide

Abstract Microglia are the immune cells in the central nervous system (CNS) and become pro-inflammatory/activated in Alzheimer’s disease (AD). Cell surface glycosylation plays an important role in immune cells; however, the N-glycosylation and glycosphingolipid (GSL) signatures of activated microgli...

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Bibliographic Details
Main Authors: Xinyu Tang, Ryan Lee Schindler, Jacopo Di Lucente, Armin Oloumi, Jennyfer Tena, Danielle Harvey, Carlito B. Lebrilla, Angela M. Zivkovic, Lee-Way Jin, Izumi Maezawa
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Microglia
Amyloid
Lipopolysaccharide
Glycosylation
Sialylation
Fucosylation
Online Access:https://doi.org/10.1038/s41598-025-96596-1
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https://doi.org/10.1038/s41598-025-96596-1

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