Phosphorylation of USP33 by CDK1 stabilizes the mTORC2 component SIN1

Phosphorylation of USP33 by CDK1 stabilizes the mTORC2 component SIN1

Abstract Understanding the mechanisms underlying chemoresistance is critical for improving cancer therapies. SIN1 plays a pivotal role in maintaining mTORC2 integrity and activation, which regulates key cellular processes. In this study, we demonstrate that elevated SIN1 expression in pancreatic duc...

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Main Authors: Yalei Wen, Caishi Zhang, Mingchao Liang, Xiao Yang, Hu Zeng, Rui Wan, Xiuqing Ma, Lei Huang, Mei Li, Qiushi Zhang, Liheng Li, Shengying Qin, Tongzheng Liu
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07869-6
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