Association between Consumption of Fluoroquinolones and Carbapenems and Their Resistance Rates in Pseudomonas aeruginosa in Argentina
Background. Irrational use of antimicrobials (ATMs) triggers microbial resistance (AMR) which has severe consequences for human health. ATM consumption varies among countries and within each territory. These data should be known, in order to perform local policies towards AMR reduction. This work ai...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2022/3924212 |
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| author | Silvia Boni Gustavo H. Marin Laura Campaña Lupe Marin Soledad Risso-Patrón Gina Marin Fernanda Gabriel Alejandra Corso Valeria Garay Manuel Limeres |
| author_facet | Silvia Boni Gustavo H. Marin Laura Campaña Lupe Marin Soledad Risso-Patrón Gina Marin Fernanda Gabriel Alejandra Corso Valeria Garay Manuel Limeres |
| author_sort | Silvia Boni |
| collection | DOAJ |
| description | Background. Irrational use of antimicrobials (ATMs) triggers microbial resistance (AMR) which has severe consequences for human health. ATM consumption varies among countries and within each territory. These data should be known, in order to perform local policies towards AMR reduction. This work aimed to expose the association of the level of consumption of carbapenems and fluoroquinolones with their resistance rates in Pseudomonas aeruginosa in Argentina. Method. Consumption of antimicrobials was expressed by defined daily dose (DDD)/1000 inhabitants for each ATM during one year period, discriminating by each country region. Resistance of P. aeruginosa to carbapenems/fluoroquinolones groups was recorded. Consumption/resistance ratio “R” was calculated for each region of the country, comparing results with other countries. Results. P. aeruginosa resistance rate to fluoroquinolone (F) was 26.4% in blood samples and 29.7% in urine samples, whereas resistance rates to carbapenems (C) were 19.9 and 17.7% in blood and urine, respectively. Correlation between consumption and resistance was demonstrated for both antimicrobials (C : R = 0.58; p=0.003 and F : R = 0.77; p=0.0001). Great fluctuations of resistance levels were seen among regions within the country, always correlating resistance with areas in which a higher level of ATM consumption was detected. Conclusion. P. aeruginosa resistance to fluoroquinolone/carbapenems in Argentina directly correlated with antimicrobial consumption levels. A great heterogeneity in resistance profile was observed among areas where ATMs were widely used. Global data at the national level might mask local realities that require specific health policies in order to control the irrational use of ATMs. |
| format | Article |
| id | doaj-art-c30cf71289c649008936a3efbf9fc3a7 |
| institution | Kabale University |
| issn | 1687-7098 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-c30cf71289c649008936a3efbf9fc3a72025-02-03T06:14:10ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-70982022-01-01202210.1155/2022/3924212Association between Consumption of Fluoroquinolones and Carbapenems and Their Resistance Rates in Pseudomonas aeruginosa in ArgentinaSilvia Boni0Gustavo H. Marin1Laura Campaña2Lupe Marin3Soledad Risso-Patrón4Gina Marin5Fernanda Gabriel6Alejandra Corso7Valeria Garay8Manuel Limeres9National Administration of Drugs, Food and Technology of ArgentinaNational Administration of Drugs, Food and Technology of ArgentinaNational Administration of Drugs, Food and Technology of ArgentinaNational University of La PlataNational Administration of Drugs, Food and Technology of ArgentinaNational University of La PlataNational Administration of Drugs, Food and Technology of ArgentinaNational Ministry of HealthNational Administration of Drugs, Food and Technology of ArgentinaNational Administration of Drugs, Food and Technology of ArgentinaBackground. Irrational use of antimicrobials (ATMs) triggers microbial resistance (AMR) which has severe consequences for human health. ATM consumption varies among countries and within each territory. These data should be known, in order to perform local policies towards AMR reduction. This work aimed to expose the association of the level of consumption of carbapenems and fluoroquinolones with their resistance rates in Pseudomonas aeruginosa in Argentina. Method. Consumption of antimicrobials was expressed by defined daily dose (DDD)/1000 inhabitants for each ATM during one year period, discriminating by each country region. Resistance of P. aeruginosa to carbapenems/fluoroquinolones groups was recorded. Consumption/resistance ratio “R” was calculated for each region of the country, comparing results with other countries. Results. P. aeruginosa resistance rate to fluoroquinolone (F) was 26.4% in blood samples and 29.7% in urine samples, whereas resistance rates to carbapenems (C) were 19.9 and 17.7% in blood and urine, respectively. Correlation between consumption and resistance was demonstrated for both antimicrobials (C : R = 0.58; p=0.003 and F : R = 0.77; p=0.0001). Great fluctuations of resistance levels were seen among regions within the country, always correlating resistance with areas in which a higher level of ATM consumption was detected. Conclusion. P. aeruginosa resistance to fluoroquinolone/carbapenems in Argentina directly correlated with antimicrobial consumption levels. A great heterogeneity in resistance profile was observed among areas where ATMs were widely used. Global data at the national level might mask local realities that require specific health policies in order to control the irrational use of ATMs.http://dx.doi.org/10.1155/2022/3924212 |
| spellingShingle | Silvia Boni Gustavo H. Marin Laura Campaña Lupe Marin Soledad Risso-Patrón Gina Marin Fernanda Gabriel Alejandra Corso Valeria Garay Manuel Limeres Association between Consumption of Fluoroquinolones and Carbapenems and Their Resistance Rates in Pseudomonas aeruginosa in Argentina Interdisciplinary Perspectives on Infectious Diseases |
| title | Association between Consumption of Fluoroquinolones and Carbapenems and Their Resistance Rates in Pseudomonas aeruginosa in Argentina |
| title_full | Association between Consumption of Fluoroquinolones and Carbapenems and Their Resistance Rates in Pseudomonas aeruginosa in Argentina |
| title_fullStr | Association between Consumption of Fluoroquinolones and Carbapenems and Their Resistance Rates in Pseudomonas aeruginosa in Argentina |
| title_full_unstemmed | Association between Consumption of Fluoroquinolones and Carbapenems and Their Resistance Rates in Pseudomonas aeruginosa in Argentina |
| title_short | Association between Consumption of Fluoroquinolones and Carbapenems and Their Resistance Rates in Pseudomonas aeruginosa in Argentina |
| title_sort | association between consumption of fluoroquinolones and carbapenems and their resistance rates in pseudomonas aeruginosa in argentina |
| url | http://dx.doi.org/10.1155/2022/3924212 |
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