Advances in Xenotransplantation: Evaluation of αGal-KO Porcine Livers and Lungs Using Normothermic Machine Perfusion in a Collaborative Perfusion Hub

Advances in Xenotransplantation: Evaluation of αGal-KO Porcine Livers and Lungs Using Normothermic Machine Perfusion in a Collaborative Perfusion Hub

Recently, initial clinical experience has been gained with the xenotransplantation of pig organs such as heart and kidney into terminally ill human patients in an effort to overcoming organ shortage. Here, we investigated the use of normothermic machine perfusion (NMP) to advance xenotransplantation...

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Main Authors: S. Stoerzer, S. Kruszona, P. Wand, H. Linge, H. Zlatev, K. Hoeffler, J. Singh, N. Roters, V. Muth, S. Tavil, A. Saipbaev, K. Cvitkovic, W. A. Kues, P. Zardo, F. Ius, J. Mengwasser, K. Splith, K. M. Schmidt-Ott, T. Goecke, R. Schwinzer, H. Niemann, A. Ruhparwar, M. Schmelzle, R. Ramm, P. Felgendreff
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Transplant International
Subjects:
xenotransplantation
liver
normothermic machine perfusion
genetically modified pigs
EVLP
perfusion hub
Online Access:https://www.frontierspartnerships.org/articles/10.3389/ti.2025.13781/full
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https://www.frontierspartnerships.org/articles/10.3389/ti.2025.13781/full

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