Human neural stem cell–derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

Human neural stem cell–derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

Human neural stem cell–derived extracellular vesicles exhibit analogous functions to their parental cells, and can thus be used as substitutes for stem cells in stem cell therapy, thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell–derived treatments. This lays...

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Bibliographic Details
Main Authors: Jiayi Wang, Mengke Zhao, Dong Fu, Meina Wang, Chao Han, Zhongyue Lv, Liang Wang, Jing Liu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-11-01
Series:Neural Regeneration Research
Subjects:
behavior
exosome
extracellular vesicles
ischemic stroke
mammalian target of rapamycin (mtor)
middle cerebral artery occlusion
neural stem cells
neuronal apoptosis
phosphoinositide 3-kinase (pi3k)
protein kinase b (akt)
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-23-01144
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https://journals.lww.com/10.4103/NRR.NRR-D-23-01144

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