Complement activity and autophagy are dysregulated in the lungs of patients with nonresolvable COVID-19 requiring lung transplantation

Complement activity and autophagy are dysregulated in the lungs of patients with nonresolvable COVID-19 requiring lung transplantation

Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced coronavirus disease 2019 (COVID-19) pandemic has challenged the current understanding of the complement cascade mechanisms of host immune responses during infection-induced nonresolvable lung disease. While the complem...

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Main Authors: Pooja Shivshankar, Stacey L. Mueller-Ortiz, Aleksey Y. Domozhirov, Weizhen Bi, Scott D. Collum, Marie-Francoise Doursout, Manish Patel, Isabella N. LeFebvre, Bindu Akkanti, Simon Yau, Howard J. Huang, Rahat Hussain, Harry Karmouty-Quintana
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Respiratory Research
Subjects:
Nonresolvable COVID-19
Pulmonary fibrosis
Complement-mediated immunity
Complement activation
Autophagy
C3a and C5a anaphylatoxins
Online Access:https://doi.org/10.1186/s12931-025-03152-6
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https://doi.org/10.1186/s12931-025-03152-6

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