Realization of immune response features by dynamical system models
Among the features of real immune responses that occur whenantigens invade a body are two remarkable features.One is that the number of antibodies produced in the secondary invasionby identical antigens is more than 10 times largerthan in the primary invasion.The other is that more effective antibo...
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| Format: | Article |
| Language: | English |
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AIMS Press
2007-04-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2007.4.531 |
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| _version_ | 1832590212107075584 |
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| author | Mika Yoshida Kinji Fuchikami Tatsuya Uezu |
| author_facet | Mika Yoshida Kinji Fuchikami Tatsuya Uezu |
| author_sort | Mika Yoshida |
| collection | DOAJ |
| description | Among the features of real immune responses that occur whenantigens invade a body are two remarkable features.One is that the number of antibodies produced in the secondary invasionby identical antigens is more than 10 times largerthan in the primary invasion.The other is that more effective antibodies, whichare produced by somatic hypermutationduring the immune response,canneutralize the antigens more quickly.This phenomenon is called''affinity maturation''.  In this paper, we try to reproduce these features bydynamical system models and present possiblefactors to realize them. Further, we present a model in whichthe memory of the antigen invasion is realized withoutimmune memory cells. |
| format | Article |
| id | doaj-art-c29c2e1cadf042359eb4512be5318daa |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2007-04-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-c29c2e1cadf042359eb4512be5318daa2025-01-24T01:53:48ZengAIMS PressMathematical Biosciences and Engineering1551-00182007-04-014353155210.3934/mbe.2007.4.531Realization of immune response features by dynamical system modelsMika Yoshida0Kinji Fuchikami1Tatsuya Uezu2Graduate School of Humanities and Sciences, Nara Women's University, Kitauoyahigashi-machi, Nara 630-8506Graduate School of Humanities and Sciences, Nara Women's University, Kitauoyahigashi-machi, Nara 630-8506Graduate School of Humanities and Sciences, Nara Women's University, Kitauoyahigashi-machi, Nara 630-8506Among the features of real immune responses that occur whenantigens invade a body are two remarkable features.One is that the number of antibodies produced in the secondary invasionby identical antigens is more than 10 times largerthan in the primary invasion.The other is that more effective antibodies, whichare produced by somatic hypermutationduring the immune response,canneutralize the antigens more quickly.This phenomenon is called''affinity maturation''.  In this paper, we try to reproduce these features bydynamical system models and present possiblefactors to realize them. Further, we present a model in whichthe memory of the antigen invasion is realized withoutimmune memory cells.https://www.aimspress.com/article/doi/10.3934/mbe.2007.4.531idiotypesomatic hypermutationimmune responseaffinitymaturation. |
| spellingShingle | Mika Yoshida Kinji Fuchikami Tatsuya Uezu Realization of immune response features by dynamical system models Mathematical Biosciences and Engineering idiotype somatic hypermutation immune response affinitymaturation. |
| title | Realization of immune response features by dynamical system models |
| title_full | Realization of immune response features by dynamical system models |
| title_fullStr | Realization of immune response features by dynamical system models |
| title_full_unstemmed | Realization of immune response features by dynamical system models |
| title_short | Realization of immune response features by dynamical system models |
| title_sort | realization of immune response features by dynamical system models |
| topic | idiotype somatic hypermutation immune response affinitymaturation. |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2007.4.531 |
| work_keys_str_mv | AT mikayoshida realizationofimmuneresponsefeaturesbydynamicalsystemmodels AT kinjifuchikami realizationofimmuneresponsefeaturesbydynamicalsystemmodels AT tatsuyauezu realizationofimmuneresponsefeaturesbydynamicalsystemmodels |