Marine fungi as a goldmine for novel antibiotics: a 2024 perspective
The microbial diversity in oceans is considerable, widely distributed in seawater, marine sediments, and marine organisms. Compared with terrestrial resources in traditional natural product research, the living environments of marine microorganisms are starkly different. The drastic differences in s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Marine Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmars.2024.1538136/full |
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| author | Chengqian Pan Syed Shams ul Hassan Ishaq Muhammad Huizi Jin |
| author_facet | Chengqian Pan Syed Shams ul Hassan Ishaq Muhammad Huizi Jin |
| author_sort | Chengqian Pan |
| collection | DOAJ |
| description | The microbial diversity in oceans is considerable, widely distributed in seawater, marine sediments, and marine organisms. Compared with terrestrial resources in traditional natural product research, the living environments of marine microorganisms are starkly different. The drastic differences in survival conditions, such as high salinity, oligotrophic conditions, lack of light, and limited oxygen, determine that microorganisms exhibit distinctive characteristics in metabolism, survival modes, and adaptive mechanisms. These factors contribute to significant distinctions in secondary metabolic pathways and enzymatic reaction mechanisms between marine and terrestrial microorganisms. In this review, we summarized a total of 72 novel natural products with antibacterial activity, published in 2024, which are derived from marine-derived fungi. These products (polyketides, alkaloids, terpenoids, and peptides) are emphasized in terms of their structures and biological activities. This article aims to provide useful information for the research and development of novel antibiotics. |
| format | Article |
| id | doaj-art-c29a6603bdbe43fa8f58385f236ecb6e |
| institution | Kabale University |
| issn | 2296-7745 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Marine Science |
| spelling | doaj-art-c29a6603bdbe43fa8f58385f236ecb6e2025-01-21T10:30:34ZengFrontiers Media S.A.Frontiers in Marine Science2296-77452025-01-011110.3389/fmars.2024.15381361538136Marine fungi as a goldmine for novel antibiotics: a 2024 perspectiveChengqian Pan0Syed Shams ul Hassan1Ishaq Muhammad2Huizi Jin3School of Pharmacy, Jiangsu University, Zhenjiang, ChinaShanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, ChinaGuangdong Key Laboratory for Research and Development of Natural Drugs, School of Pharmacy, Guangdong Medical University, Dongguan, ChinaShanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, ChinaThe microbial diversity in oceans is considerable, widely distributed in seawater, marine sediments, and marine organisms. Compared with terrestrial resources in traditional natural product research, the living environments of marine microorganisms are starkly different. The drastic differences in survival conditions, such as high salinity, oligotrophic conditions, lack of light, and limited oxygen, determine that microorganisms exhibit distinctive characteristics in metabolism, survival modes, and adaptive mechanisms. These factors contribute to significant distinctions in secondary metabolic pathways and enzymatic reaction mechanisms between marine and terrestrial microorganisms. In this review, we summarized a total of 72 novel natural products with antibacterial activity, published in 2024, which are derived from marine-derived fungi. These products (polyketides, alkaloids, terpenoids, and peptides) are emphasized in terms of their structures and biological activities. This article aims to provide useful information for the research and development of novel antibiotics.https://www.frontiersin.org/articles/10.3389/fmars.2024.1538136/fullmarine fungiantibacterial activitynovel natural productsalkaloidpolyketide |
| spellingShingle | Chengqian Pan Syed Shams ul Hassan Ishaq Muhammad Huizi Jin Marine fungi as a goldmine for novel antibiotics: a 2024 perspective Frontiers in Marine Science marine fungi antibacterial activity novel natural products alkaloid polyketide |
| title | Marine fungi as a goldmine for novel antibiotics: a 2024 perspective |
| title_full | Marine fungi as a goldmine for novel antibiotics: a 2024 perspective |
| title_fullStr | Marine fungi as a goldmine for novel antibiotics: a 2024 perspective |
| title_full_unstemmed | Marine fungi as a goldmine for novel antibiotics: a 2024 perspective |
| title_short | Marine fungi as a goldmine for novel antibiotics: a 2024 perspective |
| title_sort | marine fungi as a goldmine for novel antibiotics a 2024 perspective |
| topic | marine fungi antibacterial activity novel natural products alkaloid polyketide |
| url | https://www.frontiersin.org/articles/10.3389/fmars.2024.1538136/full |
| work_keys_str_mv | AT chengqianpan marinefungiasagoldminefornovelantibioticsa2024perspective AT syedshamsulhassan marinefungiasagoldminefornovelantibioticsa2024perspective AT ishaqmuhammad marinefungiasagoldminefornovelantibioticsa2024perspective AT huizijin marinefungiasagoldminefornovelantibioticsa2024perspective |