Transcoronary study of biomarkers in patients with heart failure: Insights into intracardiac production
Abstract Aims Biomarkers are pivotal in the management of heart failure (HF); however, their lack of cardiac specificity could limit clinical utility. This study aimed to investigate the transcoronary changes and intracardiac production of these biomarkers. Methods Transcoronary gradients for B‐type...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-06-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.15175 |
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| Summary: | Abstract Aims Biomarkers are pivotal in the management of heart failure (HF); however, their lack of cardiac specificity could limit clinical utility. This study aimed to investigate the transcoronary changes and intracardiac production of these biomarkers. Methods Transcoronary gradients for B‐type natriuretic peptide (BNP) and five novel biomarkers—galectin‐3 (Gal‐3), soluble suppression of tumourigenicity 2 (sST2), tissue inhibitor of metalloproteinase 1 (TIMP‐1), growth differentiation factor 15 (GDF‐15) and myeloperoxidase (MPO)—were determined using femoral artery (FA) and coronary sinus (CS) samples from 30 HF patients and 10 non‐HF controls. Intracardiac biomarker production was assessed in an HF canine model using real‐time quantitative PCR (qPCR) and western blot (WB) analysis. Results Compared with the control group, levels of all detected biomarkers were significantly elevated in the HF group, while transcoronary gradients were only observed for BNP, Gal‐3 and TIMP‐1 levels in the HF group (BNP: FA: 841.5 ± 727.2 ng/mL vs. CS: 1132.0 ± 959.1 ng/mL, P = 0.005; Gal‐3: FA: 9.5 ± 3.0 ng/mL vs. CS: 19.7 ± 16.4 ng/mL, P = 0.002; and TIMP‐1: FA: 286.7 ± 68.9 ng/mL vs. CS: 377.3 ± 108.9 ng/mL, P = 0.001). Real‐time qPCR and WB analysis revealed significant elevation of BNP, Gal‐3 and TIMP‐1 in the cardiac tissues of the HF group relative to other groups. Conclusions This study provided evidence of transcoronary changes in BNP, Gal‐3 and TIMP‐1 levels in HF patients, offering insights into their intracardiac production. These findings enhance the understanding of the biology of these biomarkers and may inform their clinical application. |
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| ISSN: | 2055-5822 |