The role of protein lactylation in brain health and disease: current advances and future directions

Abstract Lactate, the end product of glycolysis, plays a crucial role in cellular signaling and metabolism. The discovery of lactylation, a novel post-translational modification, has uncovered the role of lactate in regulating diseases, especially in the brain. Lactylation connects genetic encoding...

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Bibliographic Details
Main Authors: Mingrui Han, Wenfeng He, Wengen Zhu, Linjuan Guo
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02408-w
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