Severe bronchiectasis and chronic rhinosinusitis due to homozygous WFDC2 Variants: The first three cases reported from Japan

We report three cases of bronchiectasis caused by homozygous WFDC2 variants. The ages at diagnosis of bronchiectasis were 18, 24, and 16 years, and all patients had a history of chronic sinusitis since childhood. Despite low nasal nitric oxide levels, the radiologic features resembled those of cysti...

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Bibliographic Details
Main Authors: Masashi Ito, Kozo Morimoto, Minako Hijikata, Hirotsugu Hasegawa, Keiko Wakabayashi, Akiko Miyabayashi, Naoto Keicho
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Respiratory Medicine Case Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2213007125000504
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