Circulating Total and Active Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinases-1 in Patients with Systemic Lupus Erythomatosus
<p>We investigated the serum concentration of total metalloproteinase-9 (tMPP-9), active MMP-9 (aMMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) in a group of 41 patients with SLE and 20 healthy controls. Serum levels of tMMP-9 and TIMP-1 were assessed by an enzyme-linked immunoso...
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| Format: | Article |
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| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://www.hindawi.com/GetArticle.aspx?doi=10.1155/MI/2006/17898 |
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| Summary: | <p>We investigated the serum concentration of total metalloproteinase-9 (tMPP-9), active MMP-9 (aMMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) in a group of 41 patients with SLE and 20 healthy controls. Serum levels of tMMP-9 and TIMP-1 were assessed by an enzyme-linked immunosorbent assay (ELISA) and aMMP-9 by fluorometric assay. The tMMP-9 level was lower in SLE patients (mean 262 ng/mL) than in healthy volunteers (mean 325 ng/mL) (<mml:math alttext="$P=.048$"> <mml:mi>p</mml:mi> <mml:mo>=</mml:mo> <mml:mn>.048</mml:mn> </mml:math>). Similarly, aMMP-9 level was lower in SLE patients (mean 121 ng/mL) than in control group (mean 169 ng/mL) (<mml:math alttext="$P=.0355$"> <mml:mi>P</mml:mi> <mml:mo>=</mml:mo> <mml:mn>.0355</mml:mn> </mml:math>) and lower in active SLE (mean 54 ng/mL) than in inactive disease (mean 99 ng/mL) (<mml:math alttext="$P=.033$"> <mml:mi>P</mml:mi> <mml:mo>=</mml:mo> <mml:mn>.033</mml:mn> </mml:math>). TIMP-1 level was also lower in SLE patients (mean 181 ng/mL) than in control group (mean 233 ng/mL) (<mml:math alttext="$P=.004$"> <mml:mi>P</mml:mi> <mml:mo>=</mml:mo> <mml:mn>.004</mml:mn> </mml:math>). In SLE patients, a positive correlation was found between tMMP-9 and aMMP-9 (<mml:math alttext="$ ho=0.568$"> <mml:mi>ρ</mml:mi> <mml:mo>=</mml:mo> <mml:mn>0.568</mml:mn> </mml:math>; <mml:math alttext="$P=.001$"> <mml:mi>P</mml:mi> <mml:mo>=</mml:mo> <mml:mn>.001</mml:mn> </mml:math>). We also found a positive correlation of tMMP-9 and TIMP-1 with VEGF concentrations (<mml:math alttext="$ ho=0.450$"> <mml:mi>ρ</mml:mi> <mml:mo>=</mml:mo> <mml:mn>0.450</mml:mn> </mml:math>, <mml:math alttext="$P=.005$"> <mml:mi>P</mml:mi> <mml:mo>=</mml:mo> <mml:mn>.005</mml:mn> </mml:math> and <mml:math alttext="$ ho=0.387$"> <mml:mi>ρ</mml:mi> <mml:mo>=</mml:mo> <mml:mn>0.387</mml:mn> </mml:math>; <mml:math alttext="$P=.018$"> <mml:mi>P</mml:mi> <mml:mo>=</mml:mo> <mml:mn>.018</mml:mn> </mml:math>, resp). tMMP-9, aMMP-9, and TIMP-1 serum levels are lower in SLE patients than in healthy control group.</p> |
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| ISSN: | 0962-9351 |