Clinical Significance and Characterization of AZT-Resistant Strains of HIV-1
A number of laboratories have now independently confirmed that zidovudine (AZT)-resistant strains of human immunodeficiency virus type 1 (HIV-1) may be isolated from patients undergoing prolonged therapy with this drug. In certain instances, such drug-resistant viral isolates have been obtained from...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1991-01-01
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| Series: | Canadian Journal of Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/1991/124860 |
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| _version_ | 1832552387082977280 |
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| author | Mark A Wainberg Ronald Rooke Michel Tremblay XuGuang Li Michael A Parniak Qing Gao Xiao-Jian Yao Chris Tsoukas JSG Montaner M Fanning J Ruedy |
| author_facet | Mark A Wainberg Ronald Rooke Michel Tremblay XuGuang Li Michael A Parniak Qing Gao Xiao-Jian Yao Chris Tsoukas JSG Montaner M Fanning J Ruedy |
| author_sort | Mark A Wainberg |
| collection | DOAJ |
| description | A number of laboratories have now independently confirmed that zidovudine (AZT)-resistant strains of human immunodeficiency virus type 1 (HIV-1) may be isolated from patients undergoing prolonged therapy with this drug. In certain instances, such drug-resistant viral isolates have been obtained from patients with clinical acquired immune deficiency syndrome (AIDS), while in others, isolation of drug-resistant strains has been achieved in the case of HIV seropositive, asymptomatic subjects. Most of the evidence points to a series of mutations within the polymerase gene of HIV-1, which encodes viral reverse transcriptase, as being responsible for development of the drug-resistant phenotype. It further appears that over 50% of patients treated with AZT for periods longer than six months are likely to yield drug-resistant strains of HIV-1 in their circulation. Furthermore, the development of drug resistance soon after initiation of AZT therapy may potentially be correlated with the likelihood of AZT treatment failure. In several instances, cross resistance has been observed between AZT and other nucleosides being considered for potential therapy of HIV-1-associated disease. |
| format | Article |
| id | doaj-art-c25b69d438b441e4af8bd9ebcb8d9767 |
| institution | Kabale University |
| issn | 1180-2332 |
| language | English |
| publishDate | 1991-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases |
| spelling | doaj-art-c25b69d438b441e4af8bd9ebcb8d97672025-02-03T05:58:48ZengWileyCanadian Journal of Infectious Diseases1180-23321991-01-012151110.1155/1991/124860Clinical Significance and Characterization of AZT-Resistant Strains of HIV-1Mark A Wainberg0Ronald Rooke1Michel Tremblay2XuGuang Li3Michael A Parniak4Qing Gao5Xiao-Jian Yao6Chris Tsoukas7JSG Montaner8M Fanning9J Ruedy10St Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, CanadaJewish General Hospital, Montreal General Hospital and McGill AIDS Centre, McGill University, Montreal, Quebec, CanadaJewish General Hospital, Montreal General Hospital and McGill AIDS Centre, McGill University, Montreal, Quebec, CanadaJewish General Hospital, Montreal General Hospital and McGill AIDS Centre, McGill University, Montreal, Quebec, CanadaJewish General Hospital, Montreal General Hospital and McGill AIDS Centre, McGill University, Montreal, Quebec, CanadaJewish General Hospital, Montreal General Hospital and McGill AIDS Centre, McGill University, Montreal, Quebec, CanadaJewish General Hospital, Montreal General Hospital and McGill AIDS Centre, McGill University, Montreal, Quebec, CanadaToronto General Hospital, University of Toronto, Toronto, Ontario, CanadaSt Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, CanadaToronto General Hospital, University of Toronto, Toronto, Ontario, CanadaSt Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, CanadaA number of laboratories have now independently confirmed that zidovudine (AZT)-resistant strains of human immunodeficiency virus type 1 (HIV-1) may be isolated from patients undergoing prolonged therapy with this drug. In certain instances, such drug-resistant viral isolates have been obtained from patients with clinical acquired immune deficiency syndrome (AIDS), while in others, isolation of drug-resistant strains has been achieved in the case of HIV seropositive, asymptomatic subjects. Most of the evidence points to a series of mutations within the polymerase gene of HIV-1, which encodes viral reverse transcriptase, as being responsible for development of the drug-resistant phenotype. It further appears that over 50% of patients treated with AZT for periods longer than six months are likely to yield drug-resistant strains of HIV-1 in their circulation. Furthermore, the development of drug resistance soon after initiation of AZT therapy may potentially be correlated with the likelihood of AZT treatment failure. In several instances, cross resistance has been observed between AZT and other nucleosides being considered for potential therapy of HIV-1-associated disease.http://dx.doi.org/10.1155/1991/124860 |
| spellingShingle | Mark A Wainberg Ronald Rooke Michel Tremblay XuGuang Li Michael A Parniak Qing Gao Xiao-Jian Yao Chris Tsoukas JSG Montaner M Fanning J Ruedy Clinical Significance and Characterization of AZT-Resistant Strains of HIV-1 Canadian Journal of Infectious Diseases |
| title | Clinical Significance and Characterization of AZT-Resistant Strains of HIV-1 |
| title_full | Clinical Significance and Characterization of AZT-Resistant Strains of HIV-1 |
| title_fullStr | Clinical Significance and Characterization of AZT-Resistant Strains of HIV-1 |
| title_full_unstemmed | Clinical Significance and Characterization of AZT-Resistant Strains of HIV-1 |
| title_short | Clinical Significance and Characterization of AZT-Resistant Strains of HIV-1 |
| title_sort | clinical significance and characterization of azt resistant strains of hiv 1 |
| url | http://dx.doi.org/10.1155/1991/124860 |
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