B cell-extrinsic and intrinsic factors linked to early immune repletion after anti-CD20 therapy in patients with multiple sclerosis of African ancestry

B cell-extrinsic and intrinsic factors linked to early immune repletion after anti-CD20 therapy in patients with multiple sclerosis of African ancestry

IntroductionRecent investigations have identified patients of African ancestry (AA) with Multiple Sclerosis (MS), who display more rapid B-cell repopulation after standard semi-annual infusions with an anti-CD20 monoclonal antibody for B cell depletion. In this study, we explored the immunologic and...

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Bibliographic Details
Main Authors: Gregg J. Silverman, Abhimanyu N. Amarnani, Arnaldo A. Arbini, Angie Kim, Hannah Kopinsky, David Fenyo, Ilya Kister
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
Ocrelizumab
multiple sclerosis
rituximab
CD20
African ancestry
B-cell repletion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1590165/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1590165/full

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