CADD-based discovery of novel oligomeric modulators of PKM2 with antitumor activity in aggressive human glioblastoma models

CADD-based discovery of novel oligomeric modulators of PKM2 with antitumor activity in aggressive human glioblastoma models

Pyruvate kinase isoform M2 (PKM2) is a multifunctional enzyme capable of transitioning between monomeric, dimeric, and tetrameric states, with its oligomeric equilibrium playing a pivotal role in tumour progression and survival. The unique exon ten at the dimer-dimer interface represents an attracti...

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Bibliographic Details
Main Authors: Maia Cabrera, Romina Armando, Ian Czarnowski, Patricio Chinestrad, Ramiro Blanco, Alejandra Zinni, Daniel Gómez, Diego L. Mengual Gómez, Pablo Lorenzano Menna
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Heliyon
Subjects:
PKM2
Pharmacological inhibitors
Docking based virtual screening
Molecular dynamics
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844025006188
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http://www.sciencedirect.com/science/article/pii/S2405844025006188

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