Advanced flow cell design for in vitro release testing of mucoadhesive buccal films
Films for buccal application are a slowly emerging new platform for drug delivery. There remains a lack of analytical techniques for the determination of in vitro active pharmaceutical ingredient release. The aim here was to develop an alternative method to the commonly used United States Pharmacopo...
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| Format: | Article |
| Language: | English |
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Sciendo
2020-09-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2020-0030 |
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| author | Grilc Blaž Zdovc Jurij Planinšek Odon |
| author_facet | Grilc Blaž Zdovc Jurij Planinšek Odon |
| author_sort | Grilc Blaž |
| collection | DOAJ |
| description | Films for buccal application are a slowly emerging new platform for drug delivery. There remains a lack of analytical techniques for the determination of in vitro active pharmaceutical ingredient release. The aim here was to develop an alternative method to the commonly used United States Pharmacopoeia (USP) 2 method, based on the flow-through cell. This system extends the release time and enables more detailed sample discrimination according to formulation. It could be used as a tool for in vivo prediction of drug release rates from buccal film formulations. The flow cell contains two chambers separated by a membrane through which the released active pharmaceutical ingredient is measured. Vital system variables and their effects on the release rate of the model active pharmaceutical ingredient are presented for formulations based on sodium alginate polymer. The method reflects the differences between films and is shown to be discriminatory for evaluation of buccal formulations. |
| format | Article |
| id | doaj-art-c243e640aadb47d2ad8da1e627cf8d8b |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-c243e640aadb47d2ad8da1e627cf8d8b2025-02-02T17:01:55ZengSciendoActa Pharmaceutica1846-95582020-09-0170335937110.2478/acph-2020-0030acph-2020-0030Advanced flow cell design for in vitro release testing of mucoadhesive buccal filmsGrilc Blaž0Zdovc Jurij1Planinšek Odon2University of Ljubljana, Faculty of Pharmacy, Chair of Pharmaceutical Technology, 1000Ljubljana, SloveniaUniversity of Ljubljana, Faculty of Pharmacy, Chair of Pharmaceutical Technology, 1000Ljubljana, SloveniaUniversity of Ljubljana, Faculty of Pharmacy, Chair of Pharmaceutical Technology, 1000Ljubljana, SloveniaFilms for buccal application are a slowly emerging new platform for drug delivery. There remains a lack of analytical techniques for the determination of in vitro active pharmaceutical ingredient release. The aim here was to develop an alternative method to the commonly used United States Pharmacopoeia (USP) 2 method, based on the flow-through cell. This system extends the release time and enables more detailed sample discrimination according to formulation. It could be used as a tool for in vivo prediction of drug release rates from buccal film formulations. The flow cell contains two chambers separated by a membrane through which the released active pharmaceutical ingredient is measured. Vital system variables and their effects on the release rate of the model active pharmaceutical ingredient are presented for formulations based on sodium alginate polymer. The method reflects the differences between films and is shown to be discriminatory for evaluation of buccal formulations.https://doi.org/10.2478/acph-2020-0030release ratebuccal filmshydrostatic pressureflow cell |
| spellingShingle | Grilc Blaž Zdovc Jurij Planinšek Odon Advanced flow cell design for in vitro release testing of mucoadhesive buccal films Acta Pharmaceutica release rate buccal films hydrostatic pressure flow cell |
| title | Advanced flow cell design for in vitro release testing of mucoadhesive buccal films |
| title_full | Advanced flow cell design for in vitro release testing of mucoadhesive buccal films |
| title_fullStr | Advanced flow cell design for in vitro release testing of mucoadhesive buccal films |
| title_full_unstemmed | Advanced flow cell design for in vitro release testing of mucoadhesive buccal films |
| title_short | Advanced flow cell design for in vitro release testing of mucoadhesive buccal films |
| title_sort | advanced flow cell design for in vitro release testing of mucoadhesive buccal films |
| topic | release rate buccal films hydrostatic pressure flow cell |
| url | https://doi.org/10.2478/acph-2020-0030 |
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