Plasma Cell Leukemia: A Review of 3 Cases Managed in Kenya
Plasma Cell Leukemia (PCL) is a rare and aggressive form of plasma cell dyscrasia that can arise either de novo (primary plasma cell leukemia) or evolve from previously diagnosed and treated multiple myeloma (secondary PCL). We highlight three clinical cases with very different presentations as a re...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2021/4843818 |
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| _version_ | 1832546085643485184 |
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| author | Matilda Ong’ondi Elizabeth Kagotho |
| author_facet | Matilda Ong’ondi Elizabeth Kagotho |
| author_sort | Matilda Ong’ondi |
| collection | DOAJ |
| description | Plasma Cell Leukemia (PCL) is a rare and aggressive form of plasma cell dyscrasia that can arise either de novo (primary plasma cell leukemia) or evolve from previously diagnosed and treated multiple myeloma (secondary PCL). We highlight three clinical cases with very different presentations as a reminder of this diagnosis. The cases also highlight the diversity and variability that cover a patient’s journey that is highly dependent on accessibility based on financial capability and social support. The clinical presentation is more aggressive due to the higher tumour burden and more proliferative tumor cells with cytopenias being profound and more organomegaly. The diagnosis is made based on at least 20% of total white blood cells being circulating plasma cells with a peripheral blood absolute plasma cell count of at least 2 × 109/l. Treatment with novel agents followed by autologous stem cell transplant in those who are transplant eligible leads to better outcomes. |
| format | Article |
| id | doaj-art-c23b42e8bb8d45708b82fc6b7f59c19d |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-c23b42e8bb8d45708b82fc6b7f59c19d2025-02-03T07:24:02ZengWileyCase Reports in Hematology2090-65602090-65792021-01-01202110.1155/2021/48438184843818Plasma Cell Leukemia: A Review of 3 Cases Managed in KenyaMatilda Ong’ondi0Elizabeth Kagotho1Department of Internal Medicine; Hemato-oncology Unit, Kenyatta National Hospital, Nairobi, KenyaDepartment of Pathology and Laboratory Medicine, Aga Khan University hospital, Nairobi, KenyaPlasma Cell Leukemia (PCL) is a rare and aggressive form of plasma cell dyscrasia that can arise either de novo (primary plasma cell leukemia) or evolve from previously diagnosed and treated multiple myeloma (secondary PCL). We highlight three clinical cases with very different presentations as a reminder of this diagnosis. The cases also highlight the diversity and variability that cover a patient’s journey that is highly dependent on accessibility based on financial capability and social support. The clinical presentation is more aggressive due to the higher tumour burden and more proliferative tumor cells with cytopenias being profound and more organomegaly. The diagnosis is made based on at least 20% of total white blood cells being circulating plasma cells with a peripheral blood absolute plasma cell count of at least 2 × 109/l. Treatment with novel agents followed by autologous stem cell transplant in those who are transplant eligible leads to better outcomes.http://dx.doi.org/10.1155/2021/4843818 |
| spellingShingle | Matilda Ong’ondi Elizabeth Kagotho Plasma Cell Leukemia: A Review of 3 Cases Managed in Kenya Case Reports in Hematology |
| title | Plasma Cell Leukemia: A Review of 3 Cases Managed in Kenya |
| title_full | Plasma Cell Leukemia: A Review of 3 Cases Managed in Kenya |
| title_fullStr | Plasma Cell Leukemia: A Review of 3 Cases Managed in Kenya |
| title_full_unstemmed | Plasma Cell Leukemia: A Review of 3 Cases Managed in Kenya |
| title_short | Plasma Cell Leukemia: A Review of 3 Cases Managed in Kenya |
| title_sort | plasma cell leukemia a review of 3 cases managed in kenya |
| url | http://dx.doi.org/10.1155/2021/4843818 |
| work_keys_str_mv | AT matildaongondi plasmacellleukemiaareviewof3casesmanagedinkenya AT elizabethkagotho plasmacellleukemiaareviewof3casesmanagedinkenya |