CircNF1 modulates the progression and immune evasion of esophageal squamous cell carcinoma through dual regulation of PD-L1

CircNF1 modulates the progression and immune evasion of esophageal squamous cell carcinoma through dual regulation of PD-L1

Abstract Background Tumor immune escape is a pivotal gateway for esophageal squamous cell carcinoma (ESCC) development. Immune checkpoint-blocking therapies, represented by programmed cell death receptor-1/ligand 1 (PD-1/PD-L1) inhibitors, have achieved remarkable breakthroughs in ESCC treatment. Ho...

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Main Authors: Chang Wang, Chenxi Ju, Dan Du, Peiyu Zhu, Jie Yin, Jinlin Jia, Xue Wang, Xinyu Xu, Li Zhao, Junhu Wan, Ting Sun, Lijun Yang, Hongle Li, Fucheng He, Mingxia Zhou, Jing He
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cellular & Molecular Biology Letters
Subjects:
Esophageal squamous cell carcinoma (ESCC)
circRNAs
STAT3
ANXA1
PD-L1
Online Access:https://doi.org/10.1186/s11658-025-00712-y
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https://doi.org/10.1186/s11658-025-00712-y

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