Pre-clinical model of dysregulated FicD AMPylation causes diabetes by disrupting pancreatic endocrine homeostasis

Pre-clinical model of dysregulated FicD AMPylation causes diabetes by disrupting pancreatic endocrine homeostasis

The bi-functional enzyme FicD catalyzes AMPylation and deAMPylation of the endoplasmic reticulum chaperone BiP to modulate ER homeostasis and the unfolded protein response (UPR). Human hFicD with an arginine-to-serine mutation disrupts FicD deAMPylation activity resulting in severe neonatal diabetes...

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Bibliographic Details
Main Authors: Amanda K. Casey, Nathan M. Stewart, Naqi Zaidi, Hillery F. Gray, Hazel A. Fields, Masahiro Sakurai, Carlos A. Pinzon-Arteaga, Bret M. Evers, Jun Wu, Kim Orth
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Molecular Metabolism
Subjects:
AMPylation
BiP
FicD
Insulin
Islet biology
Neonatal diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000274
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