SPECT Findings in Alzheimer’s Disease and Parkinson’s Disease with Dementia
We examined, with single photon emission tomography (SPECT) and (99mTc)-HMPAO, 18 patients with idiopathic Parkinson's disease and no dementia (PD), 12 patients with PD and dementia, 24 patients with probable Alzheimer's disease (AD), and 14 controls. While the three patient groups showed...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1997-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.3233/BEN-1997-10404 |
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| author | S. E. Starkstein S. Vázquez G. Petracca L. Sabe M. Merello R. Leiguarda |
| author_facet | S. E. Starkstein S. Vázquez G. Petracca L. Sabe M. Merello R. Leiguarda |
| author_sort | S. E. Starkstein |
| collection | DOAJ |
| description | We examined, with single photon emission tomography (SPECT) and (99mTc)-HMPAO, 18 patients with idiopathic Parkinson's disease and no dementia (PD), 12 patients with PD and dementia, 24 patients with probable Alzheimer's disease (AD), and 14 controls. While the three patient groups showed significantly lower perfusion in frontal inferior and temporal inferior areas as compared to controls, both demented groups showed significantly more severe bilateral hypoperfusion in superior frontal, superior temporal and parietal areas as compared to non-demented PD patients and controls. On the other hand, no significant differences in cerebral perfusion were found between patients with AD and patients with PD and dementia. In conclusion, our findings demonstrated specific but similar cerebral perfusion deficits in demented patients with either AD or PD. |
| format | Article |
| id | doaj-art-c1ea1e50db124a1d94cc0e8db6e5839f |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 1997-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-c1ea1e50db124a1d94cc0e8db6e5839f2025-02-03T01:20:19ZengWileyBehavioural Neurology0953-41801875-85841997-01-0110412112710.3233/BEN-1997-10404SPECT Findings in Alzheimer’s Disease and Parkinson’s Disease with DementiaS. E. Starkstein0S. Vázquez1G. Petracca2L. Sabe3M. Merello4R. Leiguarda5Department of Neuropsychiatry, Raúl Carrea Institute of Neurological Research, Buenos Aires, ArgentinaDepartment of Nuclear Medicine, Raúl Carrea Institute of Neurological Research, Buenos Aires, ArgentinaDepartment of Neuropsychiatry, Raúl Carrea Institute of Neurological Research, Buenos Aires, ArgentinaDepartment of Neuropsychiatry, Raúl Carrea Institute of Neurological Research, Buenos Aires, ArgentinaDepartment of Clinical Neurology, Raúl Carrea Institute of Neurological Research, Buenos Aires, ArgentinaDepartment of Clinical Neurology, Raúl Carrea Institute of Neurological Research, Buenos Aires, ArgentinaWe examined, with single photon emission tomography (SPECT) and (99mTc)-HMPAO, 18 patients with idiopathic Parkinson's disease and no dementia (PD), 12 patients with PD and dementia, 24 patients with probable Alzheimer's disease (AD), and 14 controls. While the three patient groups showed significantly lower perfusion in frontal inferior and temporal inferior areas as compared to controls, both demented groups showed significantly more severe bilateral hypoperfusion in superior frontal, superior temporal and parietal areas as compared to non-demented PD patients and controls. On the other hand, no significant differences in cerebral perfusion were found between patients with AD and patients with PD and dementia. In conclusion, our findings demonstrated specific but similar cerebral perfusion deficits in demented patients with either AD or PD.http://dx.doi.org/10.3233/BEN-1997-10404 |
| spellingShingle | S. E. Starkstein S. Vázquez G. Petracca L. Sabe M. Merello R. Leiguarda SPECT Findings in Alzheimer’s Disease and Parkinson’s Disease with Dementia Behavioural Neurology |
| title | SPECT Findings in Alzheimer’s Disease and Parkinson’s Disease with Dementia |
| title_full | SPECT Findings in Alzheimer’s Disease and Parkinson’s Disease with Dementia |
| title_fullStr | SPECT Findings in Alzheimer’s Disease and Parkinson’s Disease with Dementia |
| title_full_unstemmed | SPECT Findings in Alzheimer’s Disease and Parkinson’s Disease with Dementia |
| title_short | SPECT Findings in Alzheimer’s Disease and Parkinson’s Disease with Dementia |
| title_sort | spect findings in alzheimer s disease and parkinson s disease with dementia |
| url | http://dx.doi.org/10.3233/BEN-1997-10404 |
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