Directed evolution of nucleotide-based libraries using lambda exonuclease

Directed evolution of nucleotide libraries using recombination or mutagenesis is an important technique for customizing catalytic or biophysical traits of proteins. Conventional directed evolution methods, however, suffer from cumbersome digestion and ligation steps. Here, we describe a simple metho...

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Bibliographic Details
Main Authors: Bee Nar Lim, Yee Siew Choong, Asma Ismail, Jörn Glökler, Zoltán Konthur, Theam Soon Lim
Format: Article
Language:English
Published: Taylor & Francis Group 2012-12-01
Series:BioTechniques
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Online Access:https://www.future-science.com/doi/10.2144/000113964
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