A Case–Control Study of the Association of Novel Androgens (11-KT and DHT), Classical Androgens (Testosterone and DHEAS), Hormones (LH, FSH, 17-OHP, Insulin, and SHBG), Insulin Resistance (HOMA-IR), and Dyslipidemia in Polycystic Ovarian Syndrome (PCOS)

Background: The measurement of androgens (testosterone and dehydroepiandrosterone sulfate (DHEAS)) remains standard for the evaluation of polycystic ovarian syndrome (PCOS) women. However, other early novel androgen markers, 5 alpha-dihydrotestosterone (DHT) and 11-ketotestosterone (11-KT), may open...

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Main Authors: Nirmal Kumar, Neera Sharma, Smita Roy, Indu Chawla, Lokesh Kumar Sharma
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-01-01
Series:Advanced Biomedical Research
Subjects:
Online Access:https://journals.lww.com/10.4103/abr.abr_262_23
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author Nirmal Kumar
Neera Sharma
Smita Roy
Indu Chawla
Lokesh Kumar Sharma
author_facet Nirmal Kumar
Neera Sharma
Smita Roy
Indu Chawla
Lokesh Kumar Sharma
author_sort Nirmal Kumar
collection DOAJ
description Background: The measurement of androgens (testosterone and dehydroepiandrosterone sulfate (DHEAS)) remains standard for the evaluation of polycystic ovarian syndrome (PCOS) women. However, other early novel androgen markers, 5 alpha-dihydrotestosterone (DHT) and 11-ketotestosterone (11-KT), may open a separate path of measurement, which may be more potent. The study was conducted with the objectives to analyze the association of 11-KT and DHT with established markers and with the clinical profile of PCOS patients. Materials and Methods: A case–control study was conducted on 30 newly diagnosed cases of PCOS as per the Rotterdam criteria and 30 age-matched controls. The estimation of testosterone, DHEAS, 11-KT, and DHT was performed by the enzyme-linked immunoassay (ELISA) method. The assessment of biochemical and hormonal parameters was compared and correlated with 11-KT and DHT. Results: Compared to the controls, cases had significantly higher 11-KT (20.81 ± 3.53 vs. 15.83 ± 2.67 nmol/L, P < 0.0001) and DHT (154.39 vs. 71.02 pg/mL, P < 0.0001). 11-KT showed a significant positive correlation with total testosterone (TT) (r = 0.555) and DHEAS (r = 0.501). DHT also showed a significant positive correlation with TT (r = 0.487) and DHEAS (r = 0.52). Conclusion: In conclusion, novel androgen derivatives (11-KT and DHT) hold equivalent evidence for the evaluation of women with PCOS as they are raised in women with PCOS as compared to controls. Moreover, they show a good correlation with the standard markers currently used for PCOS.
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spelling doaj-art-c187891d872a450ea2e2e8047880623a2025-02-06T09:41:42ZengWolters Kluwer Medknow PublicationsAdvanced Biomedical Research2277-91752025-01-011412210.4103/abr.abr_262_23A Case–Control Study of the Association of Novel Androgens (11-KT and DHT), Classical Androgens (Testosterone and DHEAS), Hormones (LH, FSH, 17-OHP, Insulin, and SHBG), Insulin Resistance (HOMA-IR), and Dyslipidemia in Polycystic Ovarian Syndrome (PCOS)Nirmal KumarNeera SharmaSmita RoyIndu ChawlaLokesh Kumar SharmaBackground: The measurement of androgens (testosterone and dehydroepiandrosterone sulfate (DHEAS)) remains standard for the evaluation of polycystic ovarian syndrome (PCOS) women. However, other early novel androgen markers, 5 alpha-dihydrotestosterone (DHT) and 11-ketotestosterone (11-KT), may open a separate path of measurement, which may be more potent. The study was conducted with the objectives to analyze the association of 11-KT and DHT with established markers and with the clinical profile of PCOS patients. Materials and Methods: A case–control study was conducted on 30 newly diagnosed cases of PCOS as per the Rotterdam criteria and 30 age-matched controls. The estimation of testosterone, DHEAS, 11-KT, and DHT was performed by the enzyme-linked immunoassay (ELISA) method. The assessment of biochemical and hormonal parameters was compared and correlated with 11-KT and DHT. Results: Compared to the controls, cases had significantly higher 11-KT (20.81 ± 3.53 vs. 15.83 ± 2.67 nmol/L, P < 0.0001) and DHT (154.39 vs. 71.02 pg/mL, P < 0.0001). 11-KT showed a significant positive correlation with total testosterone (TT) (r = 0.555) and DHEAS (r = 0.501). DHT also showed a significant positive correlation with TT (r = 0.487) and DHEAS (r = 0.52). Conclusion: In conclusion, novel androgen derivatives (11-KT and DHT) hold equivalent evidence for the evaluation of women with PCOS as they are raised in women with PCOS as compared to controls. Moreover, they show a good correlation with the standard markers currently used for PCOS.https://journals.lww.com/10.4103/abr.abr_262_23androgensdehydroepiandrosteronediagnosisdihydrotestosteroneinsulinovarysex hormone-binding globulintestosterone
spellingShingle Nirmal Kumar
Neera Sharma
Smita Roy
Indu Chawla
Lokesh Kumar Sharma
A Case–Control Study of the Association of Novel Androgens (11-KT and DHT), Classical Androgens (Testosterone and DHEAS), Hormones (LH, FSH, 17-OHP, Insulin, and SHBG), Insulin Resistance (HOMA-IR), and Dyslipidemia in Polycystic Ovarian Syndrome (PCOS)
Advanced Biomedical Research
androgens
dehydroepiandrosterone
diagnosis
dihydrotestosterone
insulin
ovary
sex hormone-binding globulin
testosterone
title A Case–Control Study of the Association of Novel Androgens (11-KT and DHT), Classical Androgens (Testosterone and DHEAS), Hormones (LH, FSH, 17-OHP, Insulin, and SHBG), Insulin Resistance (HOMA-IR), and Dyslipidemia in Polycystic Ovarian Syndrome (PCOS)
title_full A Case–Control Study of the Association of Novel Androgens (11-KT and DHT), Classical Androgens (Testosterone and DHEAS), Hormones (LH, FSH, 17-OHP, Insulin, and SHBG), Insulin Resistance (HOMA-IR), and Dyslipidemia in Polycystic Ovarian Syndrome (PCOS)
title_fullStr A Case–Control Study of the Association of Novel Androgens (11-KT and DHT), Classical Androgens (Testosterone and DHEAS), Hormones (LH, FSH, 17-OHP, Insulin, and SHBG), Insulin Resistance (HOMA-IR), and Dyslipidemia in Polycystic Ovarian Syndrome (PCOS)
title_full_unstemmed A Case–Control Study of the Association of Novel Androgens (11-KT and DHT), Classical Androgens (Testosterone and DHEAS), Hormones (LH, FSH, 17-OHP, Insulin, and SHBG), Insulin Resistance (HOMA-IR), and Dyslipidemia in Polycystic Ovarian Syndrome (PCOS)
title_short A Case–Control Study of the Association of Novel Androgens (11-KT and DHT), Classical Androgens (Testosterone and DHEAS), Hormones (LH, FSH, 17-OHP, Insulin, and SHBG), Insulin Resistance (HOMA-IR), and Dyslipidemia in Polycystic Ovarian Syndrome (PCOS)
title_sort case control study of the association of novel androgens 11 kt and dht classical androgens testosterone and dheas hormones lh fsh 17 ohp insulin and shbg insulin resistance homa ir and dyslipidemia in polycystic ovarian syndrome pcos
topic androgens
dehydroepiandrosterone
diagnosis
dihydrotestosterone
insulin
ovary
sex hormone-binding globulin
testosterone
url https://journals.lww.com/10.4103/abr.abr_262_23
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