Thapsigargin对心肌细胞钙释放和肌浆网钙容量的时问效应
【目的】肌浆网钙泵抑制剂thapsigargin (TC)常被用于耗减肌浆网(sarcoplasmic reticulum, SR)的钙 容措。本课题旨在探讨TC (I 00 nmol·L - 1)对源自SR的胞内钙释放和SR钙容损耗减的时间效应以及SR内钙 对SR钙释放的调节机理。（方法l局部场刺激作用于成年大鼠心肌细胞，使其产生动作电位，进而诱发胞内钙瞬变Caction-potential-induced Ca2 'transients, ACT)。由ACT可估测胞内钙释放。SR钙容蜇可由咖啡因(20 mmol· L -I)诱发的钙瞬变(caffeine-induced Ca2...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Journal of Sun Yat-sen University
2004-01-01
|
| Series: | Zhongshan Daxue xuebao. Yixue kexue ban |
| Online Access: | http://xuebaoyx.sysu.edu.cn/zh/article/43584974/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|