Cas12e orthologs evolve variable structural elements to facilitate dsDNA cleavage
Abstract Exceptionally diverse type V CRISPR-Cas systems provide numerous RNA-guided nucleases as powerful tools for DNA manipulation. Two known Cas12e nucleases, DpbCas12e and PlmCas12e, are both effective in genome editing. However, many differences exist in their in vitro dsDNA cleavage activitie...
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Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2024-12-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-024-54491-9 |
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