Putting a Kink in HIV-1 Particle Infectivity: Rocaglamide Inhibits HIV-1 Replication by Altering Gag-Genomic RNA Interaction

Putting a Kink in HIV-1 Particle Infectivity: Rocaglamide Inhibits HIV-1 Replication by Altering Gag-Genomic RNA Interaction

Our examination of RNA helicases for effects on HIV-1 protein production and particle assembly identified Rocaglamide (RocA), a known modulator of eIF4A1 function, as an inhibitor of HIV-1 replication in primary CD4<sup>+</sup> T cells and three cell systems. HIV-1 attenuation by low-nM...

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Bibliographic Details
Main Authors: Paul Rosenfeld, Gatikrushna Singh, Amanda Paz Herrera, Juan Ji, Bradley Seufzer, Xiao Heng, Kathleen Boris-Lawrie, Alan Cochrane
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Viruses
Subjects:
ribonucleoprotein assembly
eIF4A1
guanosine-adenosine motif
RNA structure
Online Access:https://www.mdpi.com/1999-4915/16/9/1506
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