Recent advances in near-infrared photobiomodulation for the intervention of acquired brain injury
Acquired brain injury (ABI) is an injury that affects the brain structure and function. Traditional ABI treatment strategies, including medications and rehabilitation therapy, exhibit their ability to improve its impairments in cognition, emotion, and physical activity. Recently, near-infrared (NIR)...
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| Format: | Article |
| Language: | English |
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World Scientific Publishing
2025-01-01
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| Series: | Journal of Innovative Optical Health Sciences |
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| Online Access: | https://www.worldscientific.com/doi/10.1142/S1793545824300052 |
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| author | Yujing Huang Yujing Zhang Chen Yang Mengze Xu Zhen Yuan |
| author_facet | Yujing Huang Yujing Zhang Chen Yang Mengze Xu Zhen Yuan |
| author_sort | Yujing Huang |
| collection | DOAJ |
| description | Acquired brain injury (ABI) is an injury that affects the brain structure and function. Traditional ABI treatment strategies, including medications and rehabilitation therapy, exhibit their ability to improve its impairments in cognition, emotion, and physical activity. Recently, near-infrared (NIR) photobiomodulation (PBM) has emerged as a promising physical intervention method for ABI, demonstrating that low-level light therapy can modulate cellular metabolic processes, reduce the inflammation and reactive oxygen species of ABI microenvironments, and promote neural repair and regeneration. Preclinical studies using ABI models have been carried out, revealing the potential of PBM in promoting brain injury recovery although its clinical application is still in its early stages. In this review, we first inspected the possible physical and biological mechanisms of NIR-PBM, and then reported the pathophysiology and physiology of ABI underlying NIR-PBM intervention. Therefore, the potential of NIR-PBM as a therapeutic intervention in ABI was demonstrated and it is also expected that further work can facilitate its clinical applications. |
| format | Article |
| id | doaj-art-c0f91ee90a5e45f9bcca48105d9f54ce |
| institution | Kabale University |
| issn | 1793-5458 1793-7205 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Journal of Innovative Optical Health Sciences |
| spelling | doaj-art-c0f91ee90a5e45f9bcca48105d9f54ce2025-01-27T05:49:52ZengWorld Scientific PublishingJournal of Innovative Optical Health Sciences1793-54581793-72052025-01-01180110.1142/S1793545824300052Recent advances in near-infrared photobiomodulation for the intervention of acquired brain injuryYujing Huang0Yujing Zhang1Chen Yang2Mengze Xu3Zhen Yuan4Ministry of Education, Frontiers Science Center for Precision Oncology, Faculty of Health Sciences, University of Macau, Macau SAR 999078, P. R. ChinaMinistry of Education, Frontiers Science Center for Precision Oncology, Faculty of Health Sciences, University of Macau, Macau SAR 999078, P. R. ChinaMinistry of Education, Frontiers Science Center for Precision Oncology, Faculty of Health Sciences, University of Macau, Macau SAR 999078, P. R. ChinaCenter for Cognitive and Brain Sciences, Institute of Collaborative Innovation, University of Macau, Macau SAR 999078, P. R. ChinaMinistry of Education, Frontiers Science Center for Precision Oncology, Faculty of Health Sciences, University of Macau, Macau SAR 999078, P. R. ChinaAcquired brain injury (ABI) is an injury that affects the brain structure and function. Traditional ABI treatment strategies, including medications and rehabilitation therapy, exhibit their ability to improve its impairments in cognition, emotion, and physical activity. Recently, near-infrared (NIR) photobiomodulation (PBM) has emerged as a promising physical intervention method for ABI, demonstrating that low-level light therapy can modulate cellular metabolic processes, reduce the inflammation and reactive oxygen species of ABI microenvironments, and promote neural repair and regeneration. Preclinical studies using ABI models have been carried out, revealing the potential of PBM in promoting brain injury recovery although its clinical application is still in its early stages. In this review, we first inspected the possible physical and biological mechanisms of NIR-PBM, and then reported the pathophysiology and physiology of ABI underlying NIR-PBM intervention. Therefore, the potential of NIR-PBM as a therapeutic intervention in ABI was demonstrated and it is also expected that further work can facilitate its clinical applications.https://www.worldscientific.com/doi/10.1142/S1793545824300052Near-infrared photobiomodulationacquired brain injurytraumatic brain injuryischemic stroke |
| spellingShingle | Yujing Huang Yujing Zhang Chen Yang Mengze Xu Zhen Yuan Recent advances in near-infrared photobiomodulation for the intervention of acquired brain injury Journal of Innovative Optical Health Sciences Near-infrared photobiomodulation acquired brain injury traumatic brain injury ischemic stroke |
| title | Recent advances in near-infrared photobiomodulation for the intervention of acquired brain injury |
| title_full | Recent advances in near-infrared photobiomodulation for the intervention of acquired brain injury |
| title_fullStr | Recent advances in near-infrared photobiomodulation for the intervention of acquired brain injury |
| title_full_unstemmed | Recent advances in near-infrared photobiomodulation for the intervention of acquired brain injury |
| title_short | Recent advances in near-infrared photobiomodulation for the intervention of acquired brain injury |
| title_sort | recent advances in near infrared photobiomodulation for the intervention of acquired brain injury |
| topic | Near-infrared photobiomodulation acquired brain injury traumatic brain injury ischemic stroke |
| url | https://www.worldscientific.com/doi/10.1142/S1793545824300052 |
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